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Quantification of portal venous blood flow during fasting and after a standardized meal — a MRI phase-mapping study

  • Original Articles
  • Gastrointestinal Radiology
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Abstract

Portal venous blood flow was measured with a double-oblique phase-sensitive magnetic resonance imaging (MRI) flow measurement technique in six healthy volunteers after 7 h of fasting. A standard liquid meal with an energy content of 4200 kJ, containing equal parts of carbohydrate, protein and fat was given to the volunteers while in the scanner. Flow measurements were performed 5, 15 and 30 min after intake of the meal. The average portal vein blood flow was 0.88 ± 0.17 l · min−1 during fasting. After intake of the standard meal, flow increased by 30,67 and 111% after 5, 15 and 30 min, respectively.

This study shows that a non-invasive MRI technique can be used for volume flow determinations in the portal vein and that physiological changes in flow can be quantified. The technique may be of clinical value in evaluation of patients with abdominal angina as well as patients with portal hypertension.

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References

  1. Williams DM, Eckhauser FE, Aisen A, Knol JA, Strodel WE (1987) Assessment of portosystemic shunt patency and function with magnetic resonance imaging. Surgery 102: 602–607

    Google Scholar 

  2. Yoshihara H, Sato N, Sasaki Y et al (1985) Effect on alcohol ingestion on portal venous blood flow in healthy volunteers: Comparison between the subjects with and without ALDH isozyme. Alcohol 2: 463–468

    Google Scholar 

  3. Moriyasu F, Ban N, Nishida O et al. (1986) Clinical application of an ultrasonic duplex system in the quantitative measurement of portal blood flow. J Clin Ultrasound 14: 579–588

    Google Scholar 

  4. Moriyasu F, Nishida O, Ban N et al. (1986) Measurement of portal vascular resistance in patients with portal hypertension. Gastroenterology 90: 710–717

    Google Scholar 

  5. Zoli M, Marchesini G, Cordiani MR, Pisi P, Brunori A, Trono A, Pisi E (1986) Echo-Doppler measurement of splanchnic blood flow in control and cirrhotic subjects. J Clin Ultrasound 14: 429–435

    Google Scholar 

  6. Ohnishi K, Saito M, Sato S et al. (1987) Portal Hemodynamics in Idiopathic Portal Hypertension (Banti's syndrome). Gastroenterology 92: 751–758

    Google Scholar 

  7. Ozaki CF, Anderson JC, Lieberman RP, Layton FR (1988) Duplex ultrasonography as a noninvasive technique for assessing portal hemodynamics. Am J Surg 155: 70–75

    Google Scholar 

  8. Gaiani S, Bolondi L, Bassi SL, Santi V, Zironi G, Barbara L (1989) Effect of meal on portal hemodynamics in healthy humans and patients with chronic liver disease. Hepatology 9: 815–819

    Google Scholar 

  9. Burns P, Taylor K, Blei AT (1987) Doppler flowmetry and portal hypertension. Gastroenterology 92: 824–826

    Google Scholar 

  10. Gill RW (1985) Measurement of blood flow by ultrasound: Accuracy and sources of error. Ultrasound Med Biol 11: 625–641

    Google Scholar 

  11. Higgins CB, Goldberg H, Hricak H, Crooks LE, Kaufman L, Brasch R (1983) Nuclear magnetic resonance imaging of vasculature of abdominal viscera: Normal and pathological features. AJR 140: 1217–1225

    Google Scholar 

  12. Fisher MR, Wall SD, Hricak H, McCarthy S, Kerlan RK (1985) Hepatic vascular anatomy on magnetic resonance imaging. AJR 144: 739–746

    Google Scholar 

  13. Otake S, Matsuo M, Kuroda Y (1990) Distinction of hepatic vein from portal vein by MR imaging. J Comput Assist Tomogr 14: 201–204

    Google Scholar 

  14. Silverman PM, Patt RH, Garra BS, Horii SC, Cooper C, Hayes WS, Zeman RK (1991) MR imaging of the portal venous system: Value of gradient-echo imaging as an adjunct to spin-echo imaging. AJR 157: 297–302

    Google Scholar 

  15. Williams DM, Cho KJ, Aisen AM, Eckhauser FE (1985) Portal hypertension evaluated by MR imaging. Radiology 157: 703–706

    Google Scholar 

  16. Torres WE, Gaylord GM, Whitmire L, Chuang VP, Bernardino ME (1987) The correlation between MR and angiography in portal hypertension. AJR 148: 1109–1112

    Google Scholar 

  17. Ohtomo K, Itai Y, Furui S, Yoshikawa K, Yashiro N, Iio M (1985) MR imaging of portal vein thrombus in hepatocellular carcinoma. J Comput Assist Tomogr 9: 328–329

    Google Scholar 

  18. Levy HM, Newhouse JH (1988) MR imaging of portal vein thrombosis. AJR 151: 283–286

    Google Scholar 

  19. Davy-Miallou C, Bousquet JC, Bellini MF, Guinet C, Grellet J (1990) Fausse image de thrombose porte en IRM le piège de l'hypertension portale. J Radiol 71: 27–31

    Google Scholar 

  20. White EM, Edelman RR, Wedeen VJ, Brady TJ (1986) Intravascular signal in MR imaging: Use of phase display for differentiation of blood-flow signal from intraluminal disease. Radiology 161: 245–249

    Google Scholar 

  21. Gehl HB, Bohndorf K, Klose KC, Günther RW (1990) Two-dimensional MR angiography in the evaluation of abdominal vein with gradient refocused sequences. J Comput Assist Tomogr 14: 619–624

    Google Scholar 

  22. Edelman R, Zhao B, Liu C, Wentz KU, Mattle HP, Finn JP, McArdle C (1989) MR angiography and dynamic flow evaluation of the portal venous system. AJR 153: 755–760

    Google Scholar 

  23. Tamada T, Moriyasu F, Ono S et al. (1989) Portal Blood Flow: Measurement with MR Imaging. Radiology 173: 639–644

    Google Scholar 

  24. Ståhlberg F, Mogelvang J, Thomsen C et al. (1989) A Method for MR quantification of flow velocities in blood and CSF using interleaved gradient-echo pulse sequences. Magn Reson Imaging 7: 655–667

    Google Scholar 

  25. Ståhlberg F, Ericsson A, Nordell B, Thomsen C, Henriksen O, Persson B (1992) MR imaging, flow and motion. Acta Radiologica 33: 179–200

    Google Scholar 

  26. Thomsen C, Ståhlberg F, The Scandinavian Flow Group (1989) Quantification of portal flow during a single breath hold. A double oblique through plane phase method. Society of Magnetic Resonance in Medicine, New York, Book of Abstracts 1: 469

    Google Scholar 

  27. Nordell B, Ståhlberg F, Ericsson A, Ranta C (1988) A rotating phantom for the study of flow effects of MR imaging. Magn Reson Imaging 6: 695–705

    Google Scholar 

  28. Buchardt Hansen HJ, Engell HC, Ring-Larsen H, Ranek L (1977) Splanchnic blood flow in patients with abdominal angina before and after arterial reconstruction. Am Surg 186: 216–220

    Google Scholar 

  29. Thomsen C, Ståhlberg F, Stubgaard M, Nordell B (1990) Fourier analysis of cerebrospinal fluid flow velocities: MR imaging study. Radiology 177: 659–665

    Google Scholar 

  30. Pettigrew RI, Dannels W (1987) Use of standard gradients with compound oblique angulation for optimal quantitative MR flow imaging in oblique vessels. AJR 184: 405–409

    Google Scholar 

  31. Tarnawski M, Padayachee S, West DJ, Graves MJ, Ayton VT, Taylor MG, Smith MA (1990) The measurement of time-average flow by magnetic resonance imaging using continuous acquisition in the carotid arteries and its comparison with Doppler ultrasound. Clin Phys Physiol Meas 11: 27–36

    Google Scholar 

  32. Greenway CV, Stark RD (1971) Hepatic vascular bed. Physiol Rev 51: 23–65

    Google Scholar 

  33. Schenk Jr. WJ, McDonald JC, McDonald K, Drapanas T (1962) Direct measurement of hepatic blood flow in surgical patients. Ann Surg 156: 463–469

    Google Scholar 

  34. Moreno AH, Burchell AR, Rousselot LM, Panke WF, Slafsky SF, Burke JH (1967) Portal blood flow in cirrhosis of liver. J Clin Invest 46: 436–445

    Google Scholar 

  35. Chiandussi L, Greco F, Sardi G, Vaccarino A, Ferraris CM, Curti B (1968) Estimation of hepatic arterial and portal venous blood flow by direct catheterization of the vena porta through the umbilical cord in man. Acta Hepatosplenol 15: 166–171

    Google Scholar 

  36. Sovak M, Soulen RL, Reichle F (1971) Blood flow in the human portal vein: A cineradiographic method using particulate contrast medium. Radiology 99: 531

    Google Scholar 

  37. Reichle FA, Sovak M, Soulen RL, Rosemond GP (1972) Portal vein blood flow determination in the unanesthetized human by umbilicoportal cannulation. J Surg Res 12: 146–150

    Google Scholar 

  38. Dencker H, Göthlin J, Olin T, Tibblin S (1972) Portal circulation in humans studied by a dye-dilution technique. A preliminary report. Eur Surg Res 4: 81–89

    Google Scholar 

  39. Kinoshita H, Sakai K, Kubo S, Yamazaki O (1989) Measurements of human portal blood flow by continuous thermodilution. J Surg Res 46: 235–240

    Google Scholar 

  40. Zoli M, Iervese T, Abbati S, Bianchi GP, Marchesini G, Pisi E (1989) Portal blood velocity and flow in aging man. Gerontology 35: 61–65

    Google Scholar 

  41. Norryd C, Dencker H, Lunderquist A, Olin T (1974) Superior mesenteric blood flow in man studied with a dye-dilution technique. Acta Chir Scand 141: 109–118

    Google Scholar 

  42. Orrego H, Mena I, Baranona E, Palma R (1965) Modifications in hepatic blood flow and portal pressure produced by different diets. New Series 10: 239–248

    Google Scholar 

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Authors and Affiliations

  1. Danish Research Center of Magnetic Resonance, 340 Hvidovre Hospital, DK-2650, Hvidovre, Denmark

    C. Thomsen, F. Ståhlberg & O. Henriksen

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  1. C. Thomsen
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  2. F. Ståhlberg
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  3. O. Henriksen
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Correspondence to: C. Thomsen

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Thomsen, C., Ståhlberg, F. & Henriksen, O. Quantification of portal venous blood flow during fasting and after a standardized meal — a MRI phase-mapping study. Eur. Radiol. 3, 242–247 (1993). https://doi.org/10.1007/BF00425902

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