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Attempts to induce double resistance to drugs in the flagellate, Chilomonas paramecium

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Summary

Adaptation to two antipurines, 8-azaguanine and 6-mercaptopurine, has resulted in increased resistance to the inducing agent without modifying an original resistance to sulfanilamide in a strain of Chilomonas paramecium. In the case of isoniazid, a sulfonamide-resistant strain proved to be much more susceptible than the normal strain. Adaptation has reduced this susceptibility but, so far, has not brought sensitivity back to the level of the normal strain. However, this adaptation of a sulfonamide-resistant strain to isoniazid has not appreciably decreased the original resistance to sulfanilamide.

The effects of 5-bromouracil and 2,6-diaminopurine were negligible and in each case “adaptation” caused no apparent change in a previous sulfonamide-resistance. Benzimidazole, although moderately inhibitory for all strains tested, also did not modify a preexisting sulfonamideresistance.

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Authors and Affiliations

  1. Department of Biology, New York University, New York, USA

    R. P. Hall

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  1. R. P. Hall
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To Professor Dr. E. G. Pringsheim on his 80th birthday.

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Hall, R.P. Attempts to induce double resistance to drugs in the flagellate, Chilomonas paramecium. Archiv. Mikrobiol. 42, 74–79 (1962). https://doi.org/10.1007/BF00425192

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  • DOI: https://doi.org/10.1007/BF00425192

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