Abstract
d-Amphetamine in a dose of 15 mg/kg elicits both aggressive activities and stereotyped sniffing, licking and biting of the cage in mice. A selective inhibition of the aggressive activities (without general sedation of the mice) was obtained by small doses of the neuroleptics spiramide and trifluperazine, indicating that this behaviour was mediated by increased activity of dopamine in the brain. This indication was supported by experiments with noradrenaline blocking agents and inhibitors of the synthesis of dopamine and noradrenaline.
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References
Andén, N.-E.: Effects of amphetamine and some other drugs on central catecholamine mechanisms. In: Amphetamine and Related Compounds, pp. 447–462. (E. Costa and S. Garattini, eds.). New York: Raven Press 1970.
Bandler, R.: Chemical stimultaion of the rat midbrain and aggressive behaviour. Nature (New Biol.) 229, 222–223 (1971).
Bliss, E., Ailion, J.: Response of neurogenic amines to aggregation and strangers. J. Pharmacol. exp. Ther. 168, 258–263 (1969).
Bobon, D., Janssen, P., Bobon, J. (eds.): The Neuroleptics. See i.a. papers by v. Rossum et al.; Randrup; v. Rossum. Basel: S. Karger 1970.
Chance, M.: A peculiar form of social behaviour induced in mice by amphetamine Behaviour 1, 64–70 (1948).
—, Silverman, A.: The structure of social behaviour and drug action. In: Animal behaviour and druc action. (H. Steinberg, A. de Reuck, I. Knight, eds.). London: Churchill 1964.
Cools, A., van Rossum, J.: Caudal dopamine and stereotype behaviour of cats. Arch. int. Pharmacodyn. 187, 163–173 (1970).
Costa, E., Garattini, S. (eds.): Amphetamines and related compounds. New York: Raven Press 1970.
Everett, G.: Role of dopamine in aggressive and motor responses in male mice. Pharmacologist 10, 181 (1968).
Fog, R., Randrup, A., Pakkenberg, H.: Neuroleptic action of quaternary chlorpromazine and related drugs injected into various brain areas in rats. Psychopharmacologia (Berl.) 12, 428–432 (1968).
— — —: Lesions in corpus striatum and cortex of rat brains and the effect on pharmacologically induced stereotyped, aggressive and cataleptic behaviour. Psychopharmacologia (Berl.) 18, 346–356 (1970).
— — —: Intrastriatal injection of quaternary butyrophenones and oxypertine: neuroleptic effect in rats. Psychopharmacologia (Berl.) 19, 224–230 (1971).
Gunne, L.-M.: Brain catecholamines in the rage response evoked by intracerebral stimulation and ablation. In: Aggressive behaviour, pp. 238–242. (S. Garattini and E. Sigg, eds.). Amsterdam, Excerpta Medica Foundation 1970.
Hernández-Peón, R., Chávez-Ibarra, G., Morgane, P., Timo-Iaria, C.: Limbic cholinergic pathways involved in sleep and emotional behavior. Exp. Neurol. 8, 93–111 (1963).
Janssen, P., Niemegeers, C., Schellekens, K., Dresse, A., Lenaerts, F., Pinchard, A., Schaper, W., van Nueten, J., Verbruggen, F.: Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. Arzenimittel-Forsch. (Drug Res.) 18, 261–287 (1968).
Lammers, A., van Rossum, J.: Bizarre social behaviour in rats induced by a combination of a peripheral decarboxylase inhibitor and dopa. Europ. J. Pharmacol. 5, 103–106 (1968).
Lotti, V., Porter, C.: Potentiation and inhibition of some central actions of l(−)-dopa by decarboxylase inhibitors. J. Pharmacol. exp. Ther. 172, 406–415 (1970).
Lycke, E., Modigh, K., Roos, B.-E.: Aggression in mice associated with changes in the monoamine-metabolism of the brain. Experientia (Basel) 25, 951–953 (1969).
McKenzie, G., Karpowicz, K.: Aggressive behavior in rats following apomorphine treatment and the effects of age. Pharmacologist 12, 207 (1970).
Munkvad, I., Pakkenberg, H., Randrup, A.: Aminergic systems in basal ganglia associated with stereotyped hyperactive behavior and catalepsy. Brain, Behav. Evol. 1, 89–100 (1968).
NybÄck, H., Schubert, J., Sedvall, G.: Effect of apomorphine on synthesis and turnover of labelled catecholamines in mouse brain. J. Pharm. Pharmacol. 22, 622–624 (1970).
Randrup, A., Munkvad, I.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300–310 (1967).
— —: Behavioural stereotypies induced by pharmacological agents. Pharmakopsychiat. Neuro-Psychopharmakol. 1, 18–26 (1968).
— —: Biochemical, anatomical and psychological investigations of stereotyped behaviour induced by amphetamines. Symposium on Amphetamine and Related Drugs, Milan 1969, pp. 695–713. (E. Costa and S. Garattini, eds.). New York: Raven Press 1970.
- - Correlation between specific effects of amphetamine on the brain and on behavior. Symposium on Current Concepts on Amphetamine Abuse, Duke University 1970. (E. Ellinwood, ed.) (In press.)
Reis, D., Fuxe, K.: Brain norepinephrine: Evidence that neuronal release is essential for sham rage behaviour following brainstem transection in cat. Proc. nat. Acad. Sci. (Wash.) 64, 108–112 (1969).
—, Moorehead, D., Merlino, N.: Dopa-induced excitement in the cat. Its relationship to brain norepinephrine concentrations. Arch. Neurol. (Chic.) 22, 31–39 (1970).
Rossum, J. van: Antagonism by neuroleptics of abnormal behavior induced by activation of brain dopamine receptors. In: Modern problems of pharmacopsychiatry. The Neuroleptics, vol. 5, pp. 65–67. (D. Bobon, P. Janssen, J. Bobon, eds.). Basel: S. Karger 1970.
—: The significance of dopamine-receptor blockade for the action of neuroleptic drugs. In: Neuropsychopharmacology, vol. 5, pp. 321–329. (H. Brill, ed.). Int. Congr. Ser. 129. Amsterdam: Excerpta Medica 1967.
Scheel-Krüger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Europ. J. Pharmacol. 14, 47–59 (1971).
- Studies on the accumulation of O-methylated dopamine and noradrenaline in the rat brain following various neuroleptics, thymoleptics and aceperone. Arch. int. Pharmacodyn. (in press).
—, Randrup, A.: Stereotype hyperactive behaviour produced by dopamine in the absence of noradrenaline. Life Sci. 6, 1389–1398 (1967).
— —: Aggressive behaviour provoked by pargyline in rats pretreated with diethyldithiocarbamate. J. Pharm. Pharmacol. 20, 948–949 (1968).
Senault, B.: Comportement d'aggressivité intraspecifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.) 18, 271–287 (1970).
—: Influence de l'isolement dur le comportement d'aggressivité intraspécifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.) 20, 389–394 (1971).
Silverman, A.: The effect of drugs on the social behaviour of the laboratory rat. Thesis, Birmingham University 1963.
—: The social behaviour of laboratory rats and the action of chlorpromazine and other drugs. Behaviour 27, 1–38 (1966).
Teitelbaum, P., Derks, P.: The effect of amphetamine on forced drinking in the rat. J. comp. physiol. Psychol. 51, 801–810 (1958).
Ungerstedt, U.: Postsynatpic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta physiol. scand. Suppl. 367, 69–93 (197)1.
—, Butcher, L., Butcher, S., Andén, N.-E., Fuxe, K,: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. 14, 461–471 (1969).
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Hasselager, E., Rolinski, Z. & Randrup, A. Specific antagonism by dopamine inhibitors of items of amphetamine induced aggressive behaviour. Psychopharmacologia 24, 485–495 (1972). https://doi.org/10.1007/BF00423439
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DOI: https://doi.org/10.1007/BF00423439