Abstract
Effects of 2.5, 3.75 and 5.0 mg/kg chlordiazepoxide on locomotion, rearing and preferences for novelty in rats were observed in an exploration box comprising a novel and a familiar half. Whereas an inverted U relationship between dose strength and locomotion was evident, rearing declined with increasing dosage. However, the two lower doses had little effect on preferences for novelty but 5.0 mg/kg produced a marked decrease to the point where the familiar half of the apparatus was preferred. It was concluded that estimates of drug effects on measures of locomotion or general activity are specific to those behaviours alone and do not necessarily relate to environmentally oriented exploration. Different views of the effects of drugs on exploratory behaviour might arise from the use of more valid indices, such as preferences for novelty.
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References
Ahtee, L., Shillito, E.: The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice. Brit. J. Pharmacol. 40, 361–371 (1970).
Bainbridge, J. G.: The inhibitory effect of amphetamine on exploration in mice. Psychopharmacologia (Berl.) 18, 314–319 (1970).
Berlyne, D. E.: Conflict, arousal and curiosity. New York: McGraw-Hill 1960.
Bindra, D., Spinner, N.: Response to different degrees of novelty: the incidence of various activities. J. exp. Anal. Behav. 1, 341–350 (1958).
Bolles, R. C.: Grooming behaviour in the rat. J. comp. physiol. Psychol. 53, 306–310 (1960).
Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970).
Del Rio, J., Fuentes, J. A.: Further studies on the antagonism of stereotyped behaviour induced by amphetamine. Europ. J. Pharmacol. 8, 73–78 (1969).
Dember, W. N., Earl, R. W.: Analysis of exploratory, manipulatory and curiosity behaviors. Psychol. Rev. 64, 91–96 (1957).
Dyne, L. J., Hughes, R. N.: Effects of methylphenidate on activity and reactions to novelty in rats. Psychon. Sci. 19, 267–268 (1970).
Fowler, H.: Curiosity and exploratory behavior. New York: Macmillan 1965.
Hughes, R. N.: Food deprivation and locomotor exploration in the white rat. Anim. Behav. 13, 30–32 (1965).
—: Behaviour of male and female rats with free choice of two environments differing in novelty. Anim. Behav. 16, 92–96 (1968).
—: Reactions to novelty following differential postweaning rearing and handling. Percept. mot. Skills 32, 883–886 (1971).
—, Swanberg, K. M.: Effects of food deprivation on exploration in deprivationally naive rats. Aust. J. Psychol. 22, 79–84 (1970).
Itoh, H., Takaori, S.: Effects of psychotropic agents on the exploratory behavior of rats in a Y-shaped box. Jap. J. Pharmacol. 18, 344–352 (1968).
Kršiak, M., Steinberg, H., Stolerman, I. P.: Uses and limitations of photocell activity cages for assessing effects of drugs. Psychopharmacologia (Berl.) 17, 258–274 (1970).
Kumar, R.: Exploration and latent learning: differential effects of dexamphetamine on components of exploratory behaviour in rats. Psychopharmacologia (Berl.) 16, 54–72 (1969).
Kumar, R.: Extinction of fear II: Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971).
—, Stolerman, I. P., Steinberg, H.: Psychopharmacology. Ann. Rev. Psychol. 21, 595–628 (1970).
Laverty, R., Taylor, K. M.: Behavioural and biochemical effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155) on the central nervous system. Brit. J. Pharmacol. 35, 253–264 (1969).
Leventhal, G. S., Killackey, H.: Adrenalin, stimulation and preference for novel stimuli, J. comp. physiol. Psychol. 65, 152–155 (1968).
Marriott, A. S., Spencer, P. S. J.: Effects of centrally acting drugs on exploratory behaviour in rats. Brit. J. Pharmacol. 25, 432–441 (1965).
Rosecrans, J. A.: Effects of nicotine on behavioural arousal and brain 5-hydroxytryptamine function in female rats selected for differences in activity. Europ. J. Pharmacol. 14, 29–37 (1971).
Rushton, R., Steinberg, H.: Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature (Lond.) 211, 1312–1313 (1966).
Saavedra, J. M., Heller, B., Fischer, E.: Antagonistic effect of tryptamine and Β-phenylethylamine on the behaviour of rodents. Nature (Lond.) 226, 868 (1970).
Shillito, E. E.: The effect of chlorpromazine and thioridazine on the exploration of a Y-maze by rats. Brit. J. Pharmacol. 30, 258–264 (1967).
—: A method for investigating the effects of drugs on the exploratory behaviour of mice. Brit. J. Pharmacol. 40, 113–123 (1970).
Steinberg, H., Rushton, R., Tinson, C.: Modification of the effects of an amphetamine-barbiturate mixture by the past experience of rats. Nature (Lond.) 192, 533–535 (1961).
Stone, E. A.: Swim-stress-induced inactivity: relation to body temperature and brain norepinephrin, and effects of d-amphetamine. Psychosom. Med. 32, 51–59 (1970).
Stretch, R.: Effects of amphetamine and pentobabitone on exploratory behaviour in rats. Nature (Lond.) 199, 787–789 (1963).
Thompson, T., Pickens, R.: Interoceptive stimulus control of behavior. In: T. Thompson and R. Pickens (Eds.): Stimulus properties of drugs, pp. 3–11. New York: Appleton-Century-Crofts 1971.
Valzelli, L.: The exploratory behaviour in normal and aggressive mice. Psychopharmacologia (Berl.) 15, 232–235 (1969).
Woods, P. J.: Behavior in a novel situation as influenced by the immediately preceding environment. J. exp. Anal. Behav. 5, 185–190 (1962).
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This work was supported by a research grant from the University Grants Committee (New Zealand).
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Hughes, R.N. Chlordiazepoxide modified exploration in rats. Psychopharmacologia 24, 462–469 (1972). https://doi.org/10.1007/BF00423436
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DOI: https://doi.org/10.1007/BF00423436