Psychopharmacology

, Volume 48, Issue 1, pp 101–104 | Cite as

Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

  • Mitsutaka Nakamura
  • Hideaki Fukushima
  • Sumio Kitagawa
Animal Studies Original Investigations

Abstract

Effects of amitriptyline and isocarboxazid on brain 5-HT and 5-HIAA were examined in relation to their action on 5-HTP induced head twitches. Amitriptyline reduced 5-HTP induced head twitches but isocarboxazid increased them. Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice. Amitriptyline also caused a significant increase of 5-HIAA concentration, while isocarboxazid reduced 5-HIAA concentration in the brains of 5-HTP treated mice. Probenecid, which significantly increased 5-HIAA concentration without affecting brain 5-HT concentration in 5-HTP treated mice, reduced 5-HTP induced head twitches. These results suggest that 5-HTP induced head twitches might be induced by an increase of 5-HT concentration, and reduced by an increase of 5-HIAA or a decrease of 5-HT concentration in the brains of mice.

Key words

Head twitches 5-Hydroxytryptophan Serotonin 5-Hydroxyindolacetic acid Amitriptyline Isocarboxazid Probenecid 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Mitsutaka Nakamura
    • 1
  • Hideaki Fukushima
    • 1
  • Sumio Kitagawa
    • 1
  1. 1.Research and Development Center, Pharmaceuticals DivisionSumitomo Chemical Co., Ltd.Takarazuka, HyogoJapan

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