Abstract
Discrimination eyelid conditioning was conducted under inhibitory, neutral and facilitatory instructional sets in well-practiced subjects following administration of methaphetamine, diazepam, or a placebo. Discrimination under methaphetamine was superior to the other two drug conditions, primarily as a result of decreased response levels to the unreinforced stimulus. There appeared to be no differences among drug conditions that were attributable to effects of the drugs on responsivity (nonspecific reactivity).
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References
Cole, S. O.: Experimental effects of amphetamine: A review. Psychol. Bull. 68, 81–90 (1967).
—: Note on amphetamine and food-motivated discrimination. Percept. Mot. Skills 31, 774 (1970).
Dési, I., Kertai, P., Farkas, I., Muskó, Z., Hajós, P.: The process of learning in rats undergoing prolonged treatment with psychotropic agents. Psychopharmacologia (Berl.) 18, 144–153 (1970).
Fog, R.: Behavioural effects in rats of morphine and amphetamine and of a combination of the two drugs. Psychopharmacologia (Berl.) 16, 305–312 (1970).
Franks, C., Trouton, D.: Effects of amobarbital sodium and dexamphetamine sulphate on the conditioning of the eyeblink response. J. comp. physiol. Psychol. 51, 220–222 (1958).
Galambos, E., Pfeifer, A. K., GyŐrgy, L., Molnár, J.: Study on the excitation induced by amphetamine, cocaine, and α-methyltryptamine. Psychopharmacologia (Berl.) 11, 122–129 (1967).
Gendreau, P., Suboski, M. D.: Classical discrimination eyelid conditioning in primary psychopaths. J. abnorm. Psychol. 77, 242–246 (1971a).
— —: Intelligence and age in discrimination conditioning of the eyelid response. J. exp. Psychol. 89, 379–383 (1971b).
Glick, S. D., Jarvik, M. E.: Impairment by d-amphetamine of delayed matching performance in monkeys. J. Pharmacol. exp. Ther. 169, 1–6 (1969).
Green, D. M., Swets, J. A.: Signal detection theory and psychophysics. New York: Wiley 1966.
Jonason, K. R., Lauber, S. M., Robbins, M. J., Meyer, P. M., Meyer, D. R.: Effects of amphetamine upon relearning pattern and black-white discriminations following neocortical lesions in rats. J. comp. physiol. Psychol. 73, 47–55 (1970).
Kiernan, C. C.: Modification of the effects of amphetamine sulphate by past experience in the hooded rat. Psychopharmacologia (Berl.) 8, 23–31 (1965).
Kumar, R.: Exploration and latent learning: Differential effects of dexamphetamine on components of exploratory behaviour in rats. Psychopharmacologia (Berl.) 16, 54–72 (1969).
Laties, V. G., Weiss, B.: Performance enhancement by the amphetamines: A new appraisal. In: H. Brill, J. O. Cole, P. Deniker, H. Hippius, and P. B. Bradley, eds.: Neuropsychopharmacology, pp. 800–808. New York: Excerpta Medica Foundation 1967.
Suboski, M. D.: The analysis of classical discrimination conditioning. Psychol. Bull. 68, 235–242 (1967)
—, Khosla, S.: UCS intensity and instructional set in classical eyelid conditioning: Discrimination conditioning and signal-detection analysis. Canad. J. Psychol. 23, 289–401 (1969).
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This research was supported by Grant TB 654702 from the Canadian Federal Solicitor General's Department, Penitentiaries Division, Medical Services Branch, Ottawa, Canada. A report of these data was made at the Canadian Psychological Association meeting, Toronto, 1969.
At the time of the study, students in the Faculty of Medicine at Queen's University.
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Gendreau, P., Sherlock, D., Parsons, T. et al. Effects of methaphetamine on well-practiced discrimination conditioning of the eyelid response. Psychopharmacologia 25, 112–116 (1972). https://doi.org/10.1007/BF00423188
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DOI: https://doi.org/10.1007/BF00423188