Summary
In normal dogs under pentobarbital anaesthesia, intraportal infusion of physiological doses (0.002 μg/kg/min) of cystein-treated glucagon increases markedly the plasma FFA levels in the peripheral blood. This can be considered as an argument for a possible role of glucagon as a physiological regulator of lipid metabolism.
Résumé
La perfusion portale de doses physiologiques (0.002 μg/kg/min) de glucagon traité par la cystéine augmente de façon très significative le taux sanguin des acides gras libres du plasma périphérique. Cette observation constitue un argument en faveur d'un rôle physiologique du glucagon dans le métabolisme des lipides.
Zusammenfassung
Die intraportale Infusion von physiologischen Dosen von Glucagon, das mit Cystein behandelt ist (0.002 μg/kg/min) erhöht bei normalen Hunden unter Pentobarbital-Anaesthesie eindeutig die Plasmaspiegel der freien Fettsäuren im peripheren Blut. Dieser Effekt kann als Hinweis auf die physiologische Bedeutung des Glucagons im Fettstoffwechsel angesehen werden.
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References
Dole, V.P.: A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J. clin. Invest. 35, 150–154 (1956).
Dreiling, D.A., E.L. Bierman, A.F. Debons, P. Elsbach and I.L. Schwartz: Effect of ACTH, hydrocortisone and glucagon on plasma non-esterifled fatty acid concentration (NEFA) in normal subjects and in patients with liver disease. Metabolism 11, 572–578 (1962).
Eymer, K.P., K. Schwarz and K.F. Weinges: Das Verhalten der veresterten und nichtveresterten Fettsäuren im Serum unter dem Einfluß von Glukagon und Insulin beim Menschen. Klin. Wschr. 39, 631–638 (1961).
Felber, J.P., and J.P. van Itallie: Program 40 th Meeting Endocrinol. Soc., p. 50, 1958.
Hagen, J.H.: Effects of the glucagon on the metabolism of adipose tissue. J. biol. Chem. 236, 1023–1027 (1961).
Hoffman, W.S.: A rapid photoelectric method for the determination of glucose in blood and urine. J. biol. Chem. 120, 51–55 (1937).
Lefebvre, P.: Glucagon et taux sanguin des acides gras non estérifiés chez l'homme. Ann. Endocr. (Paris) 26, 602–608 (1965).
- Contribution à l'étude du rôle physiologique du glucagon. (En préparation), 1966.
—, and Henrioul, F.: Influence du glucagon sur le taux sanguin et la différence artério-veineuse des acides gras non estérifiés. Ann. Endocr. (Paris) 24, 889–896 (1963).
Levarlet, M.: Action de l'adrénaline et du glucagon sur la glycémie, les lactates et les acides gras du plasma. C.R. Soc. Biol. 156, 1940–1942 (1962).
Lipsett, M.B., H.R. Engel and D.M. Bergenstal: Effects of glucagon on plasma unesterified fatty acids and in nitrogen metabolism. J. Lab. clin. Med. 56, 342–354 (1960).
Penick, S.B., and L.E. Jr. Hinkle: Depression of food intake induced in healthy subjects by glucagon. New Engl. J. Med. 264, 893–897 (1961).
Staub, A., and O.K. Behrens: The glucagon content of crystalline insulin preparation. J. clin. Invest. 33, 1629–1633 (1954).
Steinberg, D., E. Shafrir, and M. Vaughan: Direct effect of glucagon on release of unesterifled fatty acid (UFA) from adipose tissue. Clin. Res. 7, 250 (1959).
Unger, R.H., and A.M. Eisentraut: Studies of the physiologic role of glucagon. Diabetes, 13, 563–568 (1964).
—, A.M. Eisentraut, M.S. Mc Call and L.L. Madison with technical assistance of K.R. Sims and L. Patman: Measurements of endogenous glucagon in plasma and the influence of blood glucose upon its secretion. J. clin. Invest. 41, 682–689 (1962).
Vaughan, M., and D. Steinberg: Effect of hormones on lipolysis and esterification of free fatty acids during incubation of adipose tissue “in vitro”. J. Lipid Res. 4, 193–199 (1963).
Weinges, K.F.: Der Einfluß von Glukagon und Insulin auf den Stoffwechsel der nicht veresterten Fettsäuren am isolierten Fettgewebe der Ratte in vitro. Klin. Wschr. 39, 293–298 (1961).
—, and G. Löffler: Glucagonempfindliche lipolytische Aktivität im Fettgewebe. Klin. Wschr. 43, 175–176 (1965).
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We are gratefull to Schlichtkrull and Dr. Jersild, Novo Industri A/S, Copenhagen, for graciously providing us cystein-treated glucagon.
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Lefebvre, P. The physiological effect of glucagon on fat-mobilisation. Diabetologia 2, 130–132 (1966). https://doi.org/10.1007/BF00423023
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DOI: https://doi.org/10.1007/BF00423023