Summary
Nicotinic acid was in acute studies administered to 4 patients with untreated juvenile diabetes and to 4 obese fasting patients. In all cases the plasma level of FFA decreased. This was soon followed by a decrease in plasma β-hydroxybutyric acid. The effects were less prompt and pronounced in the obese fasting subjects. There were lesser changes in the concentration of blood glucose.
Résumé
4 malades avec diabète juvénile non-traité et 4 personnes obèses à jeun ont reçu de l'acide nicotinique dans une étude aiguë. Dans tous les cas le taux des acides gras libres du plasma descendait, suivi par une chute de l'acide bêta-hydroxybutyrique dans le plasma. Les effets étaient moins prompts et moins prononcés chez les personnes obèses à jeun. Des modifications moindres du glucose sanguin ont été observées.
Zusammenfassung
4 Patienten mit unbehandeltem, jugendlichen Diabetes und 4 Adipöse im Hungerzustand erhielten im akuten Versuch Nikotinsäure. Bei allen Versuchspersonen trat ein Abfall der freien Fettsäuren im Plasma ein, an den sich ein Absinken des β-hydroxy-buttersäure-Spiegels im Plasma anschloß. Bei den übergewichtigen Personenim Hungerzustand setzten diese Wirkungen langsamer ein und waren schwächer ausgeprägt. Die Blutzuckerspiegel änderten sich in geringerem Ausmaße.
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Carlson, L.A., Östman, J. Plasma β-hydroxybutyric acid response to nicotinic acid-induced plasma free fatty acid decrease in man. Diabetologia 2, 127–129 (1966). https://doi.org/10.1007/BF00423022
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DOI: https://doi.org/10.1007/BF00423022