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Current concepts: converting enzyme inhibitors in coronary artery disease

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Summary

Studies investigating the antiischemic action of converting enzyme inhibitors (CEIs) in patients with coronary artery disease (CAD) have, after single dosing, provided evidence for mechanisms of action such as coronary vasodilation and reduction of myocardial oxygen-consumption due to pre- and afterload reduction. Measurements of exercise-induced ST-segment depression and exercise duration as criteria for clinical efficacy have revealed contradictory findings. Patient characteristics, which may be important for a satisfactory response to CEI treatment, have yet to be identified. Patients with ischemic left ventricular dysfunction may benefit from CEI therapy. Neurohumoral factors, e.g., plasma renin activity and atrial natriuretic peptide, may also be relevant. The antiischemic efficacy of CEls given as monotherapy has not yet been convincingly demonstrated. The protective effect of CEI treatment with regard to ventricular enlargement after myocardial infarction seems to be established; however, data on mortality are still outstanding.

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Abbreviations

CEI:

converting enzyme inhibitor

NYHA IIV:

New York Heart Association Classification

CAD:

coronary artery disease

PRA:

plasma renin activity

ANP:

atrial natriuretic peptide

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  1. Abteilung für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, W-6000, Frankfurt/Main 70, Germany

    P. Thürmann & N. Rietbrock

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  1. P. Thürmann
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  2. N. Rietbrock
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Thürmann, P., Rietbrock, N. Current concepts: converting enzyme inhibitors in coronary artery disease. Clin Investig 70, 70–76 (1992). https://doi.org/10.1007/BF00422945

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