Abstract
In the absence of scheduled shocks cyclazocine (2.5 mg/kg) severely depressed avoidance responding. No behavioural excitation was observed. Behavioural excitation is observed after cyclazocine (2.5 mg/kg) injection, in the presence of scheduled shocks. The excitatory phase associated with the drug is dependent on the presence of the aversive stimulus. Thus, behaviour/drug interaction is dependent on environmental factors. The interaction of stress on psychotomimetic drug-action allows one to formulate a mechanism whereby environmental stress can play a crucial role in the genesis and underlying mechanism of schizophrenia.
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Wray, S.R. Interaction of stress and psychotomimetic drug-action: Possible implication for psychosis. Psychopharmacologia 30, 263–268 (1973). https://doi.org/10.1007/BF00422872
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DOI: https://doi.org/10.1007/BF00422872