Skip to main content
SpringerLink
Log in

Acquisition and loss of tolerance to 1-δ9-trans-tetrahydrocannabinol in rats on an avoidance schedule

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

Daily 12.0 mg/kg intraperitoneal injections of 1-δ 9-tetrahydrocannabinol produced tolerance on a number of behavioral measures in rats performing on a discriminated-Sidman avoidance schedule. Tolerance developed during a 9-day drug series and reversed completely during a similar period under vehicle-only injections.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Black, M. B., Woods, J. H., Domino, E. F.: Some effects of (−)-δ 9-transtetrahydrocannabinol and other cannabis derivatives on schedule-controlled behavior. Pharmacologist 12, 258 (1970).

    Google Scholar 

  • Bovet, D., Gatti, G. L.: Pharmacology of instrumented avoidance conditioning. Proceedings of 2nd International Pharmacological Meeting, Prague, 1963, pp. 75–89.

  • Carlini, E. A.: Tolerance to chronic administration of cannabis sativa (marihuana) in rats. Pharmacology 1, 135–142 (1968).

    Google Scholar 

  • Carlini, E. A., Hamaoui, A., Bieniek, D., Korte, F.: Effects of (−)δ 9-transtetrahydrocannabinol and a synthetic derivative on maze performance of rats. Pharmacology 4, 359–368 (1970).

    Google Scholar 

  • Chen, C. S.: A study of the alcohol-tolerance effect and an introduction of a new behavioral technique. Psychopharmacologia (Berl.) 12, 433–440 (1968).

    Google Scholar 

  • Davis, W. M., Moreton, J. E., King, W. T., Pace, H. B.: Marihuana on locomotor activity: biphasic effect and tolerance development. Res. Commun. Chem. Path. Pharmacol. 3, 29–35 (1972).

    Google Scholar 

  • Ford, R. D., McMillan, D. E.: Behavioral tolerance and cross tolerance to 1-δ 8-tetrahydrocannabinol (δ 8 THC) and 1-δ 9-tetrahydrocannabinol (δ 9 THC) in pigeons and rats. Fed. Proc. 30, 477 (1971).

    Google Scholar 

  • Kalant, H., LeBlanc, A. E., Gibbins, R. J.: Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 23, 135–191 (1971).

    Google Scholar 

  • Keehn, J. D., Webster, C. D.: Rapid discriminated bar-press avoidance through avoidance shaping. Psychonom. Sci. 10, 21–22 (1968).

    Google Scholar 

  • LeBlanc, A. E., Kalant, H., Gibbins, R. J.: Acquisition and loss of tolerance to ethanol by the rat. J. Pharmacol. exp. Ther. 168, 244–250 (1969).

    Google Scholar 

  • McMillan, D. E., Harris, L. S., Frankenheim, J. M., Kennedy, J. S.: 1-δ 9-trans-tetrahydrocannabinol in pigeons: tolerance to behavioral effects. Science 169, 501–503 (1970).

    Google Scholar 

  • Masur, J., Martz, R. M. W., Carlini, E. A.: Effects of acute and chronic administration of cannabis sativa and (−)δ 9-trans-tetrahydrocannabinol on the behavior of rats in an open-field arena. Psychopharmacologia (Berl.) 19, 388–397 (1971).

    Google Scholar 

  • Richelle, M.: A note on behavioral tolerance to meprobamate. J. exp. Anal. Behav. 8, 45–46 (1965).

    Google Scholar 

  • Sidman, M.: Some properties of the warning signal in avoidance behavior. J. comp. physiol. Psychol. 48, 444–450 (1955).

    Google Scholar 

  • Silva, M. T., Carlini, E. A., Claussen, U., Korte, F.: Lack of cross-tolerance in rats among(−)δ 9-trans-tetrahydrocannabinol (δ 9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25). Psychopharmacologia (Berl.) 13, 332–340 (1968).

    Google Scholar 

  • Smythies, J. R., Johnston, V. S., Bradley, R. J.: Behavioral models of psychosis. Brit. J. Psychiat. 115, 55–68 (1969).

    Google Scholar 

  • Webster, C. D., Willinsky, M. D., Herring, B. S., Walters, G. C.: Effects of 1-δ 1-tetrahydrocannabinol on temporally spaced responding and discriminated Sidman avoidance behaviour in rats. Nature (Lond.) 232, 498–501 (1971).

    Google Scholar 

  • Webster, C. D., Herring, B. S., Jupiter, H., Willinsky, M. D.: Effects of 1-δ 1-tetrahydrocannabinol on discriminated Sidman avoidance behavior in rats during prolonged sessions. Paper presented at Tenth Annual Meeting of Psychonomic Society, San Antonio, Texas 1970.

  • Willinsky, M. D., Webster, C. D., Herring, Barbara S.: Effects of δ 1-tetrahydrocannabinol on Sidman discriminated avoidance behavior in rats. Paper presented at 7 th International Congress of Neuropsychopharmacology, Prague 1970.

Download references

Author information

Author notes

  1. C. D. Webster

    Present address: The Clarke Institute of Psychiatry, M5T 1 R8, Toronto, Canada

  2. J. M. Beaton

    Present address: The Medical Center, the University of Alabama in Birmingham, UK

Authors and Affiliations

  1. Addiction Research Foundation, Toronto, Canada

    C. D. Webster, A. E. LeBlanc, Joan A. Marshman & J. M. Beaton

  2. Department of Pharmacology, University of Toronto, Canada

    A. E. LeBlanc

Authors
  1. C. D. Webster
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. E. LeBlanc
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joan A. Marshman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. M. Beaton
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Work completed at Addiction Research Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Webster, C.D., LeBlanc, A.E., Marshman, J.A. et al. Acquisition and loss of tolerance to 1-δ9-trans-tetrahydrocannabinol in rats on an avoidance schedule. Psychopharmacologia 30, 217–226 (1973). https://doi.org/10.1007/BF00422868

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00422868

Key words

Search

Navigation