Abstract
The injections of morphine into rats which had been made tolerant to morphine produced stereotyped sniffing, licking and biting reminiscent of amphetamine-stereotypy. Pretreatment with drugs acting on the brain catecholamines such as reserpine, H 44/68, FLA-63 and receptor blockers could inhibit this behaviour. Comparison between morphine and amphetamine stereotypy indicated that brain noradrenaline plays a more important role than dopamine in morphine induced stereotyped behaviour, in contrast to amphetamine stereotypy where dopamine is the most important brain amine. The result of experiments with intraventricular injections of noradrenaline supported this conclusion, because the noradrenaline suppressed the blocking action of FLA-63 on morphine-induced stereotypy.
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Ayhan, I.H., Randrup, A. Role of brain noradrenaline in morphine-induced stereotyped behaviour. Psychopharmacologia 27, 203–212 (1972). https://doi.org/10.1007/BF00422800
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DOI: https://doi.org/10.1007/BF00422800