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Psychopharmacologia

, Volume 26, Issue 3, pp 313–316 | Cite as

Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties

  • Martin D. Schechter
  • John A. Rosecrans
Animal Studies

Abstract

Rats were trained to choose between the arms of a T-maze apparatus according to whether they were injected i.p. with 0.1 Μmol/kg LSD or 0.9% saline. The LSD drug-state acquired the properties of a discriminative stimulus, possibly by producing interoceptive cues. Doses of 9.0 Μmol/kg psilocybin and 90 and 120 Μmol/kg mescaline produced cueing effects which were not significantly different from the cueing effect of LSD. However, d-amphetamine (14.8 and 29.6 Μmol/kg) did not appear to produce an LSD-like cue. These results suggest that LSD, mescaline and psilocybin, when administered in functionally equivalent doses, produce qualitatively similar interoceptive cues in the rat.

Key words

LSD Mescaline Psilocybin State-Dependent Learning 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Martin D. Schechter
    • 1
  • John A. Rosecrans
    • 1
  1. 1.Department of PharmacologyMedical College of VirginiaRichmondUSA

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