Abstract
Small doses of ethanol (1 or 2 g/kg 20% w/v) caused increased motor activity in rats and mice as measured by an Animex activity meter. This effect was prevented by pretreatment with the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine methyl ester hydrochloride, in doses of 40 or 200 mg/kg which per se caused no significant depression of motor activity. The data implicate a role for newly synthesized catecholamines in ethanol-induced motor stimulation.
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Carlsson, A., Engel, J. & Svensson, T.H. Inhibition of ethanol-induced excitation in mice and rats by α-methyl-p-tyrosine. Psychopharmacologia 26, 307–312 (1972). https://doi.org/10.1007/BF00422706
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DOI: https://doi.org/10.1007/BF00422706