Abstract
In two separate experiments effects were evaluated of chronic administration of δ-9-THC (i.v.) on the behavior of rhesus monkeys trained on a multiple schedule of food reinforcement and a shock avoidance schedule. Rapid tolerance to drug effect was observed on avoidance responding; but only partial tolerance on food reinforced responding. Only a minor degree of tolerance was noted on gross behavior. In both experiments, tolerance to the drug carried over a 30-day drugfree period.
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Research supported by NIMH grant MH 19651.
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Harris, R.T., Waters, W. & McLendon, D. Behavioral effects in rhesus monkeys of repeated intravenous doses of δ-9-tetrahydrocannabinol. Psychopharmacologia 26, 297–306 (1972). https://doi.org/10.1007/BF00422705
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DOI: https://doi.org/10.1007/BF00422705