Abstract
The effect of reserpine and tetrabenazine pretreatment on tremorine induced analgesia has been studied in mice by clip, hot plate and electric shock methods. Reserpine and tetrabenazine pretreatment significantly increased the ED50 of tremorine by all methods. Replacement of endogenous catecholamines and 5-hydroxytryptamine by treatment with dl-DOPA and dl-5-HTP did not block the anti-analgesic effect of reserpine on tremorine induced analgesia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bianchi, C., Franceschini, J.: Experimental observations on Haffner's method for testing analgesic drugs. Brit. J. Pharmacol. 9, 280–284 (1954).
Brodie, B. B., Spector, S., Shore, P. A.: Interaction of drugs with norepinephrine in the brain. Pharmacol. Rev. 11, 548–564 (1959).
Costa, E., Gessa, G. L., Kuntzman, R., Brodie, B. B.: The effect of drugs on storage and release of serotonin and catecholamines in the brain. First Int. Pharmacol. Meeting, Vol. 8, pp. 43–99. Ed. by B. Uvnas. Oxford: Pergamon Press 1962.
Howes, J. F., Harris, L. S., Dewey, W. L., Vodya, C. A.: Brain acetylcholine levels and inhibition of the tail flick reflex in mice. J. Pharmacol. exp. Ther. 169, 23–28 (1969).
Green, A. F.: Antihypertensive drugs. Advances in Pharmacology, vol. 1, pp. 162 to 220. Ed. by S. Garattini and P. A. Shore. New York: Academic Press 1962.
Grewal, R. S.: A method for testing analgesia in mice. Brit. J. Pharmacol. 7, 433–437 (1952).
Litchfield, J. T., Wilcoxon, F.: A simplified method of evaluating dose effect experiments. J. Pharmacol. exp. Ther. 96, 99–113 (1949).
Major, C. T., Pleuvry, B. J.: Effects of α-methyl-p-tyrosine, p-chlorophenylalanine, 1-Β(3,4 dihydroxyphenyl) alanine, 5 hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in mouse. Brit. J. Pharmacol. 42, 512–521 (1971).
Radouco-Thomas, S., Radouco-Thomas, C., Breton, E.: Action de la noradrenaline et de la reserpine sur l'analgesia experimentale. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 232, 279–281 (1957).
—, Singh, P., Gracin, F., Radouco-Thomas, C.: Relationship between experimental analgesia and brain monoamines: catecholamines and 5 hydroxytryptamine. Arch. Biol. Med. exp. 4, 42–62 (1967).
Sethy, V. H., Naik, S. R., Sheth, U. K.: The effect of drugs influencing amine synthesis on the analgesic action of tremorine. Psychopharmacologia (Berl.) 19, 73–80 (1971).
—, Pradhan, R. J., Mandrekar, S. S., Sheth, U. K.: Role of brain amines in the analgesic action of meperidine hydrochloride. Psychopharmacologia (Berl.) 17, 320–326 (1970).
Takagi, H., Takashim, T., Kimura, K.: Antagonism of the analgesic effect of morphine in mice by tetrabenazine and reserpine. Arch. int. Pharmacodyn. 149, 484–492 (1964).
Tenan, S. S.: Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor. Psychopharmacologia (Berl.) 12, 278–285 (1968).
Author information
Authors and Affiliations
Additional information
This work was supported by the research grant from the Council of Scientific and Industrial Research, India.
Rights and permissions
About this article
Cite this article
Sethy, V.H., Naik, S.R. & Sheth, U.K. Effect of reserpine and tetrabenazine on tremorine analgesia in mice. Psychopharmacologia 26, 249–254 (1972). https://doi.org/10.1007/BF00422700
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00422700