Abstract
There are many advantages in determining platelet aggregation in whole blood. The ability to carry out the assay more or less immediately the sample has been taken (i.e., without the need to prepare platelet rich plasma), and the testing of platelets in their natural environment (i.e., in the presence of red and white cells) are considered the two most important of these advantages.
This paper describes the use of a continuous counting technique with a modified Technicon Autocounter, with reference to a similar ability to use sequential counting techniques with modern haematology analysers.
Preliminary results using rat blood and two reference compounds are also reported.
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References
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Holmes IB, Freuler F (1979) Use of the Technicon Autocounter for animal platelet counting and for continuous monitoring of circulating platelet numbers. Pharmacol Ther 5: 257
Smith GM, Freuler F (1973) The measurement of intravascular aggregation by continuous platelet counting. Bibl Anat 12: 229
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Hardy, M.J., Walker, A.K., Brown, G. et al. Whole blood platelet aggregometry using continuous/sequential counting techniques. Comparative Haematology International 1, 52–54 (1991). https://doi.org/10.1007/BF00422694
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DOI: https://doi.org/10.1007/BF00422694