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δ9-tetrahydrocannabinol effect on audiogenic seizure susceptibility

Psychopharmacologia volume 29, pages 101–106 (1973)Cite this article

Abstract

Mice, normally not susceptible to audiogenic seizures, can be made susceptible by exposing the animal to a loud auditory stimulus (priming) and then retesting the same animal at a later time (retest). δ 9-Tetrahydrocannabinol (THC) was found to decrease susceptibility when administered either prior to priming or prior to retest. This decrease in susceptibility was dependent upon both time and dose. The effectiveness of THC in blocking seizures when administered before priming points to a relatively unique action of this compound. In general, it appears the THC is active at loci involved in predetermining convulsive states precipitated by auditory stimuli.

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References

  • Bicher, H. I., Machoulam, R.: Pharmacological effects of two active constituents of marihuana. Arch. int. Pharmacodyn. 172, 24–31 (1968).

    Google Scholar 

  • Bobbin R. P., Gonzalez, G., Guth, P. S.: Effects of aminooxyacetic acid on cochlear potentials and the Preyer reflex. Nature (Lond.) 223, 70 (1969).

    Google Scholar 

  • Boggan, W. O., Freedman, D. X., Lovell, R. A., Schlesinger, K.: Studies in audiogenic seizure susceptibility. Psychopharmacologia (Berl.) 20, 48–56 (1971).

    Google Scholar 

  • Bose B. C., Saifi, A. Q., Bhagwat, A. W.: Effect of cannabis indica on hexobarbital sleeping time and tissue respiration of rat brain. Arch. int. Pharmacodyn. 141 520–524 (1963).

    Google Scholar 

  • Carlini, E. Z., Kramer, C.: Effects of Cannabis sative (marihuana) on maze performance of the rat. Psychopharmacologia (Berl.) 7, 175–181 (1965).

    Google Scholar 

  • Dagirmanjian, R., Boyd, E. S.: Some pharmacological effects of two tetrahydrocannabinols. J. Pharmacol. exp. Ther. 135, 25–33 (1962).

    Google Scholar 

  • Fuller, J. L., Collins, R. L.: Mice unilaterally sensitized for audiogenic seizures. Science 162, 1295 (1968).

    Google Scholar 

  • Garattini S.: Effects of a cannabis extract on gross behavior. In: Hashish: its chemistry and pharmacology. G. Wolstenholme and J. Knight eds. Ciba Foundation Study Group no. 21. Boston: Little Brown 1965.

    Google Scholar 

  • Garriott, J. C., King L. J., Forney, R. B., Hughes, F. W.: Effect of some tetrahydrocannabinols on hexabarbital sleeping time and amphetamine induced hyperactivity in mice. Life Sci. 6, 2119–2128 (1967).

    Google Scholar 

  • Henry, K. R.: Audiogenic seizure susceptibility induced in C57BL/6J mice by prior auditory exposure. Science 158, 938–940 (1967).

    Google Scholar 

  • Ho, B. T., Fritchie, E., Englert, L. F., McIsaac, E. M., Heikkila, J. E.: Marihuana: importance of the route of administration. J. Pharm. Pharmacol. 23, 309–310 (1971).

    Google Scholar 

  • Holtzman, D., Lovell, R. A., Jaffe, J. H., Freedman, D. X.: 1-δ 9-tetrahydrocannabinol: neurochemical and behavioral effects in the mouse. Science 163, 1464–1467 (1969).

    Google Scholar 

  • Kaymakcalan, S., Deneau, G. A.: Some pharmacological effects of synthetic δ 9-tetrahydrocannabinol (THC). Pharmacologist 12, 310 (1970).

    Google Scholar 

  • Loewe, S., Goodman, L. S.: Anticonvulsant action of marihuana-active substances. Fed. Proc. 6, 352 (1947).

    Google Scholar 

  • Phillips, R. N., Turn, R. F., Forney, R. B.: Acute toxicity of δ 9-tetrahydrocannabinol in rats and mice. Proc. Soc. exp. Biol. (N.Y.) 136, 260–263 (1971).

    Google Scholar 

  • Santos, M., Sampaio, M. R. P., Fernandes, N. S., Carlini, E. A.: Effects of Cannabis sative (marihuana) on the fighting behavior of mice. Psychopharmacologia (Berl.) 8, 437–444 (1966).

    Google Scholar 

  • Scheckel, C. L., Boff, E., Dahlen, P., Smart, T.: Behavioral effects in monkeys of racemates of two biologically active marihuana constituents. Science 160, 1467–1469 (1968).

    Google Scholar 

  • Sofia, R. D., Solomon, T. A., Barry, H.: The anticonvulsant activity of δ 1-tetrahydrocannabinol in mice. Pharmacologist 13, 309 (1971).

    Google Scholar 

  • Sze, P. Y.: Neurochemical factors in auditory stimulation and development of susceptibility to audiogenic seizures. In: Physiological effects of noise. B. L. Welch and A. S. Welch, eds. New York: Plenum Press 1970.

    Google Scholar 

  • Truitt, E. B.: Pharmacological activity of a metabolite of 1-trans-δ 8-tetrahydrocannabinol. Fed. Proc. 29, 2095 (1970).

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, The University of Chicago, USA

    William O. Boggan, Ronald A. Steele & Daniel X. Freedman

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  1. William O. Boggan
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  2. Ronald A. Steele
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  3. Daniel X. Freedman
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Additional information

This research was supported by research grants State of Illinois Public Welfare 17-302 and W. C. and J. V. Stone Foundation (W. O. B.).

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Boggan, W.O., Steele, R.A. & Freedman, D.X. δ9-tetrahydrocannabinol effect on audiogenic seizure susceptibility. Psychopharmacologia 29, 101–106 (1973). https://doi.org/10.1007/BF00422641

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  • DOI: https://doi.org/10.1007/BF00422641

Key words

  • δ 9-Tetrahydrocannabinol
  • Marihuana
  • Convulsions
  • Audiogenic Seizures