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δ9-tetrahydrocannabinol effect on audiogenic seizure susceptibility

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Abstract

Mice, normally not susceptible to audiogenic seizures, can be made susceptible by exposing the animal to a loud auditory stimulus (priming) and then retesting the same animal at a later time (retest). δ 9-Tetrahydrocannabinol (THC) was found to decrease susceptibility when administered either prior to priming or prior to retest. This decrease in susceptibility was dependent upon both time and dose. The effectiveness of THC in blocking seizures when administered before priming points to a relatively unique action of this compound. In general, it appears the THC is active at loci involved in predetermining convulsive states precipitated by auditory stimuli.

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Authors and Affiliations

  1. Department of Psychiatry, The University of Chicago, USA

    William O. Boggan, Ronald A. Steele & Daniel X. Freedman

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  1. William O. Boggan
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  2. Ronald A. Steele
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  3. Daniel X. Freedman
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Additional information

This research was supported by research grants State of Illinois Public Welfare 17-302 and W. C. and J. V. Stone Foundation (W. O. B.).

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Boggan, W.O., Steele, R.A. & Freedman, D.X. δ9-tetrahydrocannabinol effect on audiogenic seizure susceptibility. Psychopharmacologia 29, 101–106 (1973). https://doi.org/10.1007/BF00422641

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  • DOI: https://doi.org/10.1007/BF00422641

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