Abstract
Minor tranquilizers typically fail to facilitate learned behaviors suppressed by CER or punishment. However, this study found a disruption of a temporal discrimination (Pavlovian Inhibition of Delay) based on conditioned suppression. After 230 trials for nine rats, greatest suppression occurred at the end of the CS (inhibition of delay). Drug, but not saline, disrupted this discrimination, and the data were interpreted in terms of Pavlovian excitation and inhibition.
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The authors acknowledge with appreciation the suggestions of David Margules and the contribution of oxazepam by Wyeth Laboratories. This research was supported by NIMH grants MH 16540 to LJH. Reprints may be obtained by writing to Jack D. Maser who is now at the Department of Psychology, Tulane University, New Orleans, Louisiana 70118.
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Maser, J.D., Hammond, L.J. Disruption of a temporal discrimination by the minor tranquilizer, oxazepam. Psychopharmacologia 25, 69–76 (1972). https://doi.org/10.1007/BF00422618
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DOI: https://doi.org/10.1007/BF00422618