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Psychopharmacologia

, Volume 25, Issue 1, pp 41–48 | Cite as

The effects of methylamphetamine on stereotyped behaviour, activity, startle, and orienting responses

  • Robert J. Kirkby
  • David S. Bell
  • Alan C. Preston
Animal Studies

Abstract

In two experiments the relationships between methylamphetamine induced stereotyped behaviour and locomotory activity, startle reactivity, and orienting responsiveness were investigated in laboratory rats. Experiment I showed that administration of 5 mg/kg methylamphetamine, compared to 0.5 mg/kg methylamphetamine or saline, resulted in increased stereotypy, increased startle reactivity, and decreased orienting. Experiment II confirmed that the higher dose of methylamphetamine enhanced startle reactivity, and indicated that concomitant with this, habituation to successive startle stimuli was inhibited. The similarities between stereotypy in the rat and schizophreniform behaviour in the human were discussed.

Key words

Methylamphetamine Stereotyped Behaviour Activity Startle Response Orienting Response Schizophrenia 

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References

  1. Bainbridge, J. G.: The inhibiting effect of amphetamine on exploration in mice. Psychopharmacologia (Berl.) 18, 314–319 (1970).Google Scholar
  2. Bridger, W. H., Mandel, J. J.: The effects of dimethamzyphenylethylamine and mescaline on classical conditioning in rats as measured by the potentiated startle response. Life Sci. 6, 775–781 (1967).Google Scholar
  3. Cladel, C. E., Cho, M. H., McDonald, R. D.: Effect of amphetamine and catecholamines on startle response and general motor activity of albino rats. Nature (Lond.) 210, 864–865 (1966).Google Scholar
  4. Davis, M., Wagner, A. R.: Habituation of startle response under incremental sequence of stimulus intensities. J. comp. physiol. Psychol. 67, 486–492 (1969).Google Scholar
  5. Duffy, E.: The psychological significance of the concept of “arousal” or “activation”. Psychol. Rev. 64, 265–275 (1957).Google Scholar
  6. Easterbrook, J. A.: The effect of emotion on cue utilization and the organization of behaviour. Psychol. Rev. 66, 183–201 (1959).Google Scholar
  7. Hebb, D. O.: Drives and the C.N.S. (conceptual nervous system). Psychol. Rev. 62, 243–254 (1955).Google Scholar
  8. Janssen, P. A., Niemegeers, C. U., Schellekens, K. H.: Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? Arzneimittel-Forsch. 15, 104–117 (1965).Google Scholar
  9. Lammers, A. J., Van Rossum, J. M.: Bizarre social behaviour in rats induced by a combination of a peripheral decarboxylase inhibitor and DOPA. Europ. J. Pharmacol. 5, 103–106 (1968).Google Scholar
  10. Moyer, K. E.: Startle response; habituation over trials and days, and sex and strain differences. J. comp. physiol. Psychol. 56, 863–865 (1963).Google Scholar
  11. Munkvad, I., Randrup, A.: The persistence of amphetamine stereotypies of rats in spite of strong sedation. Acta psychiat. scand., Suppl. 191, 178–187 (1966).Google Scholar
  12. Prosser, C. L., Hunter, W. S.: The extinction of startle responses and spinal reflexes in the white rat. Amer. J. Physiol. 117, 609–618 (1936).Google Scholar
  13. Randrup, A., Munkvad, I.: Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia (Berl.) 11, 300–310 (1967).Google Scholar
  14. —: Pharmacological studies on the brain mechanisms underlying two forms of behavioural excitation: Stereotyped hyperactivity and rage. Ann. N. Y. Acad. Sci. 159, 928–938 (1969).Google Scholar
  15. —, Udsen, P.: Adrenergic mechanisms and amphetamine induced abnormal behaviour. Acta pharmacol. (Kbh.) 20, 145–157 (1963).Google Scholar
  16. SchiØrring, E.: Amphetamine induced selective stimulation of certain behaviour items with concurrent inhibition of others in an open-field test with rats. Behaviour 39, 1–17 (1971).Google Scholar
  17. Venables, P. H., Wing, J. K.: Level of arousal and the subclassification of schizophrenia. Arch. gen. Psychiat. 1, 114–119 (1962).Google Scholar
  18. Yates, A. J.: Psychological deficit. Ann. Rev. Psychol. 17, 111–144 (1966).Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Robert J. Kirkby
    • 1
  • David S. Bell
    • 1
  • Alan C. Preston
    • 1
  1. 1.Psychiatric Research UnitCallan Park HospitalRozelleAustralia

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