Hypoxia-induced amnesia in one-trial learning and pharmacological protection by piracetam
Rats were given Piracetam or saline 30 min orally before one trial passive avoidance training; after training they were submitted to nitrogen induced hypoxia (“Sudden” and “Progressive” procedure) or were confined to the hypoxia cage with a normal atmosphere.
hypoxia prevented the avoidance response on day 2 for the saline injected animals and
Piracetam protected the animals from this hypoxia induced amnesia. The results are discussed in terms of electrophysiological and biochemical modifications which have been found to be associated with both hypoxia and Piracetam.
Key wordsHypoxia Memory Consolidation One Trial Learning Piracetam
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- Bureš, J., Burešová, O.: Cortical spreading depression as a memory disturbing factor. J. comp. physiol. Psychol. 56, 268–272 (1963).Google Scholar
- Giurgea, C. E., Lefevre, D., Leserenier, C., David-Remacle, M.: Pharmacological protection against hypoxia induced amnesia in rats. Psychopharmacologia (Berl.) 20, 160–168 (1971).Google Scholar
- —, Mouravieff-Lesuisse, F.: Effet facilitateur du Piracetam sur un apprentissage répétitif chez le rat. J. Pharmacol. (Paris) 3, 17–30 (1972).Google Scholar
- —: Pharmacological studies on an elementary model of learning. The fixation of an experience at spinal level. Part I: Pharmacological reactivity of the spinal cord fixation time. Arch. int. Pharmacodyn. 191, 279–291 (1971B).Google Scholar
- —, Leemans, R.: Corrélations électro-pharmacologiques au cours de l'anoxie oxyprive chez le lapin en respiration libre ou artificielle. Rev. neurol. 122, 484–486 (1970).Google Scholar
- —, Moyersoons, F.: Differential reactivity of three types of cortical evoked potentials. Arch. int. Pharmacodyn. 188, 401–404 (1970).Google Scholar
- Gobert, J. G., van de Walle, A. J., Close, J. A.: In vivo modifications of the rat brain metabolism induced by Piracetam. Second part: Hypoxied rats. (In press).Google Scholar
- Gottesfeld, Z., Miller, A. T., Jr.: Metabolic response of rat to acute hypoxia: influence of polycythemia and hypercapnia. Amer. J. Physiol. 216, 1374–1379 (1969).Google Scholar
- Hayes, K. J.: Anoxic and convulsive amnesia in rats. J. comp. physiol. Psychol. 46, 216–217 (1953).Google Scholar
- Lefevre, D., Sara, S.: A reexamination of the role of familiarization (FAM) in retrograde amnesia (RA) in the rat. (In press.)Google Scholar
- Lowry, O. H., Passonneau, J. V., Hasselberger, F. X., Schulz, D. W.: Effect of ischaemia on known substrates and cofactor of the glycolytic pathway in brain. J. biol. Chem. 239, 18–30 (1964).Google Scholar
- Moyersoons, F., Evraerd, A., Dauby, J., Giurgea, C. E.: A particular pharmacological effect on the propagation of experimental strychnine and penicillin epilepsy. Arch. int. Pharmacodyn. 179, 388–400 (1969).Google Scholar
- Spector, R. G.: Water content of the brain in anoxia-ischaemic encephalopathy in adult rats. Brit. J. exp. Path. 42, 623–630 (1961).Google Scholar
- —: Cerebral succinic dehydrogenase, cytochrome oxidase and mono-amine oxidase activity in experimental anoxic-ischaemic brain damage. Brit. J. Path. 44, 251–254 (1963).Google Scholar
- Taber, R. I., Banuazizi, A.: CO2 induced retrograde amnesia in an one-trial learning situation. Psychopharmacologia (Berl.) 9, 382–391 (1966).Google Scholar
- Thompson, R.: The comparative effects of ECS and anoxia on memory. J. comp. physiol. Psychol. 50, 397–400 (1957).Google Scholar
- Pryer, R. S.: The effect of anoxia on the retention of a discrimination habit. J. comp. physiol. Psychol. 49, 297–300 (1956).Google Scholar
- Vacher, J. M., King, R. A., Miller, A. T., Jr.: Failure of hypoxia to produce retrograde amnesia. J. comp. physiol. Psychol. 66, 179–181 (1968).Google Scholar