Psychopharmacologia

, Volume 25, Issue 1, pp 32–40 | Cite as

Hypoxia-induced amnesia in one-trial learning and pharmacological protection by piracetam

  • S. J. Sara
  • D. Lefevre
Animal Studies

Abstract

Rats were given Piracetam or saline 30 min orally before one trial passive avoidance training; after training they were submitted to nitrogen induced hypoxia (“Sudden” and “Progressive” procedure) or were confined to the hypoxia cage with a normal atmosphere.

Results showed that
  1. 1.

    hypoxia prevented the avoidance response on day 2 for the saline injected animals and

     
  2. 2.

    Piracetam protected the animals from this hypoxia induced amnesia. The results are discussed in terms of electrophysiological and biochemical modifications which have been found to be associated with both hypoxia and Piracetam.

     

Key words

Hypoxia Memory Consolidation One Trial Learning Piracetam 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • S. J. Sara
    • 1
    • 2
  • D. Lefevre
    • 1
    • 2
  1. 1.Center of Experimental and Comparative PsychologyUniversity of LouvainBelgium
  2. 2.Department of PharmacologyUCB-DiphaBrusselsBelgium

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