A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant

Abstract

In depressions, varying therapeutic effects have been obtained with 5-HT precursors. This is possibly due to the fact that the group of the depressions is pathogenetically heterogeneous; that, specifically, some types do and other types do not entail disturbances in the central 5-HT metabolism; and that only the former types are “precursor-sensitive”. This hypothesis was tested in a preliminary pilot study, and confirmed. The central 5-HT consumption was assessed on the basis of the probenecid test. In this experiment, 5-HTP was for the first time given in large doses over a considerable period of time.

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This study was supported by grants from the Netherlands Organization for Pure Research (Z.W.O.), the “Preventie Fonds” and the Merck Sharp & Dohme Research Laboratories (U.S.A.).

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van Praag, H.M., Korf, J., Dols, L.C.W. et al. A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant. Psychopharmacologia 25, 14–21 (1972). https://doi.org/10.1007/BF00422612

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Key words

  • Depression
  • Serotonin Hypothesis
  • Probenecid Test
  • 5-Hydroxytryptophan
  • Antidepressants