, Volume 25, Issue 1, pp 14–21 | Cite as

A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant

  • H. M. van Praag
  • J. Korf
  • L. C. W. Dols
  • T. Schut
Human Pharmacology


In depressions, varying therapeutic effects have been obtained with 5-HT precursors. This is possibly due to the fact that the group of the depressions is pathogenetically heterogeneous; that, specifically, some types do and other types do not entail disturbances in the central 5-HT metabolism; and that only the former types are “precursor-sensitive”. This hypothesis was tested in a preliminary pilot study, and confirmed. The central 5-HT consumption was assessed on the basis of the probenecid test. In this experiment, 5-HTP was for the first time given in large doses over a considerable period of time.

Key words

Depression Serotonin Hypothesis Probenecid Test 5-Hydroxytryptophan Antidepressants 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • H. M. van Praag
    • 1
  • J. Korf
    • 1
  • L. C. W. Dols
    • 1
  • T. Schut
    • 1
  1. 1.Department of Biological Psychiatry and Department of Clinical PsychologyPsychiatric University ClinicGroningenThe Netherlands

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