Abstract
Rats were trained to discriminate between two levers utilizing drug-induced physiological states as discriminative stimuli. Drug injections were associated with reinforcement of response on one lever and saline was associated with reinforcement on the other lever. At equimolar doses, d- and l-amphetamine but not para-hydroxyamphetamine, functioned effectively as cues. Following training, stimulus generalization between these drugs was evaluated. Transfer of response control was observed between the d- and l-isomers, and between para-hydroxyamphetamine and saline in rats trained to utilize d- or l-amphetamine versus saline as cues. These findings suggest the importance of central pharmacological activity in this type of response control.
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References
Barry, H., Kubena, R. K.: Discriminative stimulus characteristics of alcohol, marihuana and atropine. In: Drug Addiction: Experimental Pharmacology. J. M. Singh, L. H. Miller, and H. Lal, Eds., Vol. 1, pp. 3–16. Mount Kisco, New York: Futura Publ. Comp. 1972
Brodie, B. B., Cho, A. K., Gessa, G. L.: Possible role of p-hydroxynorephedrine in the depletion of norepinephrine induced by d-amphetamine and in tolerance to this drug. In: Amphetamine and related compounds. E. Costa and S. Garattini, Eds., pp. 217–230. New York: Raven Press 1970
Brown, A., Feldman, R. S., Moore, J. W.: Conditional discrimination learning based upon chlordiazepoxide: Dissociation or Cue? J. comp. physiol. Psychol. 66, 211–215 (1968)
Clay, G. H., Cho, A. K., Roberfroid, M.: Effect of diethlyaminoethyl diphenyl-propylacetate hydrochloride (SKF-525A) on the norepinephrine depleting actions of d-amphetamine. Biochem. Pharmacol. 20, 1821–1831 (1971)
Conger, J. J.: The effects of alcohol on conflict behavior in the albino rat. Quart. J. Stud. Alcohol 12, 1–29 (1951)
Costa, E., Naimzada, M. K., Revuelta, A.: Pharmacological implications of the effects of amphetamine and its analogs on the turnover rate of tissue catecholamines. In: Brain chemistry and mental disease: Advances in behavioral biology. B. T. Ho and W. M. McIsaac, Eds. Vol. 1, pp. 83–96. New York: Plenum Press 1971
Harris, R. T., Balster, R. L.: An analysis of the function of drugs in the stimulus control of operant behavior. In stimulus properties of drugs. T. Thompson and R. Pickens, Eds., pp. 111–132. New York: Appleton-Century-Crofts 1971
Hill, H. F.: Evidence that amphetamine hyperthermia is produced by an action of the drug on the CNS. Fed. Proc. 30, 206 (1971)
Innes, I. R., Nickerson, M.: Drugs acting on postganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs). In: The Pharmacological basis of therapeutics. L. S. Goodman, and A. Gilman, Eds., 4th edit., pp. 478–523. New York: The McMillan Comp. 1970
Kilbey, M. M., Harris, R. T., Aigner, T. G.: Establishment of equivalent external and internal stimulus control of an operant behavior and its reversal. Proceedings, 79th Annual Convention, A.P.A., op. 767–768 (1971)
Kubena, R. K., Barry, H.: Two procedures for training differential responses in alcohol and non drug conditions. J. pharm. Sci. 58, 99–101 (1969a)
Kubena, R. K., Barry, H.: Generalization by rats of alcohol and atropine stimulus characteristics to other drugs. Psychopharmacologia (Berl.) 15, 196–206 (1969b)
Kubena, R. K., Barry, H.: Stimulus characteristics of marijuana components. Nature (Lond.) 235, 397–398 (1972)
Lewander, T.: Displacement of brain and heart noradrenaline by p-hydroxynorephedrine after administration of p-hydroxyamphetamine. Acta pharmacol. (Kbh.) 29, 20–32 (1971a)
Lewander, T.: On the presence of p-hydroxynorephedrine in the rat brain and heart in relation to changes in catecholamine levels after administration of amphetamine. Acta pharmacol. (Kbh.) 29, 33–48 (1971b)
Moore, K. E.: Toxicity and catecholamine releasing action of d- and l-amphetamine in isolated and aggregated mice. J. Pharmacol. exp. Ther. 142, 6–12 (1963)
Morrison, C. F., Stephenson, J. A.: Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia (Berl.) 15, 351–360 (1969)
Overton, D. A.: State-dependent of “dissociated” learning produced with pentobarbital. J. comp. physiol. Psychol. 57, 3–12 (1964)
Overton, D. A.: State-dependent learning produced by depressant and atropine-like drugs. Psychopharmacologia (Berl.) 10, 6–31 (1966)
Overton, D. A.: Discriminative control by drugs states. In: Stimulus properties of drugs. T. Thompson and R. Pickens, Eds., pp. 87–110. New York: Appleton-Century-Crofts 1971
Richards, D. W. III, Harris, R. T., Ho, B. T.: Central control of d-amphetamine-induced discriminative stimulus. Paper presented at the 3rd annual meeting of the Society for Neurosciences, San Diego 1973
Schechter, M. D.: Transfer of state-dependent behavior between subcutaneously and intraventrioularly administered nicotine and saline. Psychopharmacologia (Berl.) 32, 327–335 (1973)
Schechter, M. D., Rosecrans, J. A.: CNS effect of nicotine as the discriminative stimulus for the rat in T-maze. Life Sci. 10, 821–832 (1971)
Schechter, M. D., Rosecrans, J. A.: d-Amphetamine as a discriminative cue: Drugs with similar stimulus propertied. Europ. J. Pharmacol. 21, 212–216 (1973)
Stewart, J.: Differential responses based on the physiological consequences of pharmacological agents. Psychopharmacologia (Berl.) 3, 132–138 (1962)
Taylor, K. M., Snyder, S. H.: Amphetamine: Differentiation by d- and l-isomers of behavior involving brain norepinephrine and dopamine. Science 168, 1487–1489 (1970)
Waters, W. H., Richards, D. W., Harris, R. T.: Discriminative control and generalization of the stimulus properties of dl-amphetamine in the rat. In: Drug Addiction: Experimental Pharmacology. J. M. Singh, L. H. Miller, and H. Lal., Eds., Vol. 1, pp. 87–98. Mount Kisco, New York: Futura Publ. Comp. 1972
Winer, B. J.: Statistical Principles in experimental design. New York: McGraw-Hill 1962
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This research was supported by National Institute of Mental Health Grant MH-19651.
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Jones, C.N., Hill, H.F. & Harris, R.T. Discriminative response control by d-amphetamine and related compounds in the rat. Psychopharmacologia 36, 347–356 (1974). https://doi.org/10.1007/BF00422566
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DOI: https://doi.org/10.1007/BF00422566