, Volume 36, Issue 4, pp 301–312 | Cite as

Acute and chronic effects of LSD and 3,4-dimethoxyphenylethylamine on shuttlebox escape/avoidance in rats

  • David M. Stoff
  • Irwin J. Mandel
  • David A. Gorelick
  • Wagner H. Bridger
Animal Studies


Three experiments were conducted in rats to study the effects of acute and chronic LSD and 3,4-dimethoxyphenylethylamine (DMPEA) on acquisition of shuttlebox escape/avoidance and of acute DMPEA on performance in the shuttlebox of pretrained poor performers. In Experiments 1 and 2, separate groups of male hooded rats were injected (i.p.) either once with LSD (0.1 or 0.5 mg/kg),DMPEA (25, 50, or 100 mg/kg) or saline or daily for 5 days with LSD (0.5 mg/kg), DMPEA (25 or 100 mg/kg) or saline before an initial acquisition test. The acute drug groups were retested 24 h later under saline. In Experiment 3, pretrained rats which had achieved a low, stable baseline rate of shuttlebox performance were injected once with DMPEA (50 mg/kg) before a performance test and retested 24 h later under saline. It was found that all LSD treatments decreases escape/avoidance latencies (excitatory effect) on the acquisition test and saline retest, while all DMPEA treatments were without effect.

Key words

LSD 3,4-Dimethoxyphenylethylamine DMPEA Tolerance Shuttlebox Escape/Avoidance Acquisition 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • David M. Stoff
    • 1
    • 5
  • Irwin J. Mandel
    • 2
  • David A. Gorelick
    • 3
  • Wagner H. Bridger
    • 4
  1. 1.Department of PsychiatryAlbert Einstein College of MedicineBronx
  2. 2.Department of PsychologyQueens College of City University of New YorkFlushing
  3. 3.Department of PharmacologyAlbert Einstein College of MedicineBronx
  4. 4.Department of PsychiatryAlbert Einstein College of MedicineBronx
  5. 5.Laboratory of Clinical Psychopharmacology, Division of Special Mental Health ResearchIRP, NIMH, Saint Elizabeth HospitalWashington, D. C.

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