Abstract
Sch 12679, N-methyl-l-phenyl-7,8-dimethoxy-2,3,4,5-tetrahydro-3-benzazepine maleate, is active in a broad spectrum of laboratory models of aggressive behavior without producing any signs of neurologic impairment up to lethal doses. Sch 12679 is an effective inhibitor of isolation-induced aggression in mice, muricide and septal lesion-induced aggression in rats and spontaneous aggression in Rhesus monkeys. Sch 12679 also antagonizes methamphetamine aggregate toxicity in mice and hypothalmic self-stimulation in rats as do major tranquilizers; however, it differs from major tranquilizers in that it does not affect conditioned avoidance response (CAR) performance or produce catalepsy, ptosis or hypothermia. Sch 12679 does not fit into established profiles for either minor or major tranquilizers or other existing types of psychopharmacological agents. Initial clinical studies have confirmed that Sch 12679 reduces aggressive behavior without producing concomitant sedation.
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A preliminary report of this work was presented to the American Society for Pharmacology and Experimental Therapeutics in San Francisco, California, July 23–28, 1972.
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Barnett, A., Taber, R.I. & Steiner, S.S. The behavioral pharmacology of Sch 12679. A new psychoactive agent. Psychopharmacologia 36, 281–290 (1974). https://doi.org/10.1007/BF00422560
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DOI: https://doi.org/10.1007/BF00422560