, Volume 25, Issue 3, pp 275–280 | Cite as

Analgesic activity of δ9-tetrahydrocannabinol in the rat and mouse

  • D. M. Buxbaum
Animal Studies


An analysis of the analgesic activity of δ9-tetrahydrocannabinol (δ9-THC) was carried out in rats and mice using both the hot plate and tail flick tests. In the rat, the dose-effect curve of δ9-THC was comparable to that of morphine in both tests. In the mouse, however, the THC dose-effect curves were more variable and less steep than the morphine dose-effect curves. THC was less potent than morphine in both tests in mice. THC analgesia reached its peak at one hour and had a longer duration of action than morphine.

Key words

Tetrahydrocannabinol Morphine Analgesia Cannabis 


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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • D. M. Buxbaum
    • 1
    • 2
  1. 1.Department of PharmacologyVanderbilt University School of MedicineUSA
  2. 2.Tennessee Neuropsychiatric InstituteCentral State HospitalNashville

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