Analgesic activity of δ9-tetrahydrocannabinol in the rat and mouse
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An analysis of the analgesic activity of δ9-tetrahydrocannabinol (δ9-THC) was carried out in rats and mice using both the hot plate and tail flick tests. In the rat, the dose-effect curve of δ9-THC was comparable to that of morphine in both tests. In the mouse, however, the THC dose-effect curves were more variable and less steep than the morphine dose-effect curves. THC was less potent than morphine in both tests in mice. THC analgesia reached its peak at one hour and had a longer duration of action than morphine.
Key wordsTetrahydrocannabinol Morphine Analgesia Cannabis
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