Abstract
Platelet monoamine oxidase activity was determined in 52 unipolar depressive patients, 26 patients with bipolar affective disorder and 48 controls using phenylethylamine as substrate. Unipolar depressive patients of either sex and bipolar depressive women showed significantly higher platelet MAO activity than controls. Women had higher activity than men. Neither age nor serum lithium level correlated with enzyme activity and there was no significant change in activity after the institution of lithium treatment.
Similar content being viewed by others
References
Belmaker RH, Ebbesen K, Ebstein R, Rimon R (1976) Platelet monoamine oxidase in schizophrenia and manic-depressive illness. Br J Psychiatry 129:227–232
Berrettini WH, Vogel WH, Ladman RK (1979) Effects of lithium therapy on MAO in manic-depressive illness. Am J Psychiatry 136:836–838
Bockar J, Roth R, Heninger G (1974) Increased human platelet monoamine oxidase activity during lithium carbonate therapy. Life Sci 15:2109–2118
Edwards DJ, Spiker DG, Kupfer DJ, Foster G, Neil JF, Abrams L (1978) Platelet monoamine oxidase in affective disorders. Arch Gen Psychiatry 35:1443–1446
Glover V, Sandler M, Hughes A, Hoffbrand AV (1980) Platelet monoamine oxidase activity in megaloblastic anaemia. J Clin Pathol 33:963–965
Gottfries CG, Oreland L, Wiberg A, Winblad B (1975) Lowered monoamine oxidase activity in brains from alcoholic suicides. J Neurochem 25:667–673
Grote SS, Moses SG, Robins E, Hudgens RW, Croninger AB (1974) A study of selected catecholamine metabolizing enzymes: a comparison of depressive suicides and alcoholic suicides with controls. J Neurochem 22:791–802
Johnston JP (1968) Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem Pharmacol 17:1285–1297
Landowski J, Lysiak W, Angielski S (1975) Monoamine oxidase activity in blood platelets from patients with cyclophrenic depressive syndromes. Biochem Med 14:347–354
Leckman JF, Gershon ES, Nichols AS, Murphy DL (1977) Reduced MAO activity in first-degree relatives of individuals with bipolar affective disorders. Arch Gen Psychiatry 34:601–606
Lewinsohn R, Böhm K-H, Glover V, Sandler M (1978) A benzylamine oxidase distinct from monoamine oxidase B—widespread distribution in man and rat. Biochem Pharmacol 27:1857–1863
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265–275
Mann J (1979) Altered platelet monoamine oxidase activity in affective disorders. Psychol Med 9:729–736
Medical Research Council (1965) Clinical trial of the treatment of depressive illness. Br Med J 1:881–886
Murphy DL, Weiss R (1972) Reduced monoamine oxidase activity in blood platelets from bipolar depressed patients. Am J Psychiatry 128:1351–1357
Murphy DL, Wright C, Buchsbaum M, Nichols A, Costa JL, Wyatt RJ (1976) Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time. Biochem Med 16:254–265
Nies A, Robinson DS, Harris LS, Lamborn KR (1974) Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives, and controls. In: Usdin E (ed), Neuropsycho-pharmacology of monoamines and their regulatory enzymes. Raven Press, New York, pp 59–70
Nies A, Robinson DS, Ravaris CL, Davis JM (1971) Amines and monoamine oxidase in relation to aging and depression in man. Psychosom Med 33:470
Orsulak PJ, Schildkraut JJ, Schatzberg AF, Herzog JM (1978) Differences in platelet monoamine oxidase activity in subgroups of schizophrenic and depressive disorders. Biol Psychiatry 13:637–647
Pandey GN, Dorus EB, Dekirmenjian H, Davis JM (1975) Effect of lithium treatment of blood catechol-O-methyl transferase and platelet monoamine oxidase in normal human subjects. Fed Proc 34:778
Robinson DS, Davis JM, Nies A, Colburn RW, Davis JN, Bourne HR, Bunney WE, Shaw DM, Coppen A (1972) Ageing, monoamines, and monoamine oxidase levels. Lancet I:290–291
Robinson DS, Davis JM, Nies A, Ravaris CL, Sylvester D (1971) Relation of sex and aging to monoamine oxidase activity of human brain, plasma, and platelets. Arch Gen Psychiatry 24:536–539
Sullivan JL, Cavenar JO, Maltbie A, Stanfield C (1977) Platelet monoamine oxidase activity predicts response to lithium in manicdepressive illness. Lancet II:1325–1327
Wyatt RJ, Potkin SG, Murphy DL (1979) Platelet monoamine oxidase activity in schizophrenia: a review of the data. Am J Psychiatry 136:377–385
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Reveley, M.A., Glover, V., Sandler, M. et al. Increased platelet monoamine oxidase activity in affective disorders. Psychopharmacology 73, 257–260 (1981). https://doi.org/10.1007/BF00422413
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00422413