Abstract
The effects of neonatal and adult administrations of gonadal hormones were investigated on the activity of regional brain choline acetylase (ChAc) and fighting behavior in the mouse. It was found that, generally, the hormonal treatments resulted in consistent increases in hypothalamic and hippocampal ChAc, and inconsistent changes in cortical ChAc. Increases in enzyme activity were not accompanied by similar increases in fighting. There was a lack of positive correlation between a particular gonadal hormone used, the increase in ChAc and fighting A number of hypotheses are proposed.
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This investigation was supported in part by an allocation from General Research Support Grant FR-05545 from the Division of Research Resources to The Jackson Laboratory and in part by Training Grant GY-7614 from the National Science Foundation.
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Eleftheriou, B.E., Dobson, C.L. Effects of neonatal and adult treatments with gonadal hormones on choline acetylase activity in brain regions of male mice after fighting. Psychopharmacologia 27, 45–52 (1972). https://doi.org/10.1007/BF00421955
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DOI: https://doi.org/10.1007/BF00421955