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The effect of 1-δ1-trans-tetrahydrocannabinol on learning and retention of avoidance performance in rats

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Abstract

Forty-eight rats were trained for 1 h and tested the next day for 1 h on a discriminated Sidman avoidance task in a 2×2 crossover design using tetrahydrocannabinol (THC) and placebo. A dose of 4 mg/kg impaired performance on Day 2, but improved Day 1 learning. It is shown that this method can elucidate some of the mechanisms through which a drug works.

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Authors and Affiliations

  1. Addiction Research Foundation, Toronto, Ontario, Canada

    Barbara Herring

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  1. Barbara Herring
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Herring, B. The effect of 1-δ1-trans-tetrahydrocannabinol on learning and retention of avoidance performance in rats. Psychopharmacologia 26, 401–406 (1972). https://doi.org/10.1007/BF00421906

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  • DOI: https://doi.org/10.1007/BF00421906

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