Abstract
Oglesby, Rosenberg, Winter: Behavioral and biochemical effects of chronic administration of bromide in the rat. Bromide, a sedative in low doses and a psychotogen in high doses in man, was tested for behavioral and biochemical effects in the rat. The kinetics of bromide excretion following chronic administration were studied in the rat to determine drug regimens necessary to achieve stable, non-lethal levels of blood bromide. When administered daily to animals performing on a variable-interval schedule of positive reinforcement (VI 44), a low dose of bromide increased rates of responding while a high dose depressed response rates. Following withdrawal of the drug after six weeks of administration, response rates returned to previously determined control levels. Chlorpromazine failed to antagonize bromide-induced rate depression. No change in the concentration of norepinephrine or 5-hydroxytryptamine was seen with any dose of bromide studied.
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References
Dews, P. B.: Studies on behavior. I. Differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward. J. Pharmacol. exp. Ther. 113, 393–401 (1955)
Glowinski, J., Iversen, L. L.: Regional studies of catecholamines in the rat brain. Int. J. Neurochem. 13, 655–669 (1966)
Goldstein, A., Aronow, L., Kalman, S. M.: Principles of drug action, pp. 292, 309–311. New York: Harper and Row 1969
Goodwin, J. S., Katz, R. I., Kopin, I. J.: Effect of bromide on evoked release of monoamides from brain slices and intact atria. Nature (Lond.) 221, 556–557 (1969)
Huette, C.: Recherches sur les proprietes physiologiques et therapeutiques du bromare de potassium. C. R. Soc. Biol. (Paris) 2, 19–35 (1850)
Isbell, H.: Bromides. In: Textbook of medicine, pp. 145–146. P. B. Beeson and W. McDermott, ed. Philadelphia: W. B. Saunders 1971
Kelleher, R. T., Morse, W. H.: Determinations of the specificity of drugs. In: Review of physiology, biochemistry and experimental pharmacology, Vol. 60, pp. 2–56. Berlin-Heidelberg-New York: Springer 1968
Kurijama, D.: Association of bromide with synaptosomal fraction of mouse brain. Life Sci. 9, 1371–1381 (1970)
Rosenblum, I.: Non-specific effect of bromide on conditioned avoidance behavior in rats. Proc. Soc. exp. Biol. (N. Y.) 103, 214–215 (1960)
Soremark, R.: The biological half-life of bromide in human blood. Acta physiol. scand. 50, 119–123 (1960)
Stein, L.: Neurochemistry of reward and punishment: some implications for the etiology of schizophrenia. J. Psychiat. Res. 8, 345–361 (1971)
Sunshine, I.: Bromide, type b procedure. CR Manual of analytical toxicology. Cleveland, Ohio: The Chemical Rubber Comp. 1971
Welch, A. S., Welch, B. L.: Solvent extraction for simultaneous determination of norepinephrine, dopamine, serotonin and 5-hydroxyindole-acetic acid in a single mouse brain. Analyt. Biochem. 30, 161–179 (1969)
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Oglesby, M.W., Rosenberg, J. & Winter, J.C. Behavioral and biochemical effects of chronic administration of bromide in the rat. Psychopharmacologia 32, 85–92 (1973). https://doi.org/10.1007/BF00421710
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DOI: https://doi.org/10.1007/BF00421710