Summary
Mapping and transcription studies have revealed that in Podospora anserina the causative agent of senescence, a mitochondrial plasmid (p1DNA), is identical with intronl of the discontinuous gene for cytochrome-c-oxidase subunit 1 (COI), which is 2 kpb from the discontinuous gene for cytochrome b (Cytb). A mitochondrial mutant (ex1) devoid of the COI, but not of the Cytb gene provides longevity. A molecular model for the onset of senescence is presented.
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Kück, U., Osiewacz, H.D., Schmidt, U. et al. The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina . Curr Genet 9, 373–382 (1985). https://doi.org/10.1007/BF00421608
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DOI: https://doi.org/10.1007/BF00421608