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Tolerance in methylphenidate-induced locomotion in prairie dogs (cynomys ludovicianus)

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Abstract

After a five-day adaptation period in activity wheels, four prairie dogs were assigned to a methylphenidate group (2.5 mg/kg, s.c.) and four prairie dogs were assigned to a saline group for ten consecutive daily injections. Half-revolutions of locomotor activity were recorded during seven measurement periods taken daily. During the third measurement period, from 1–3 hrs following injection, the methylphenidate group declined in locomotor activity over the first three days of drug administration.

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Author notes

  1. W. Gibson Wood

    Present address: Department of Psychology, Syracuse University, Syracuse, New York

Authors and Affiliations

  1. Department of Psychology, Texas Tech University, Lubbock, Texas, USA

    Henry L. Schreiber, W. Gibson Wood & Richard H. Carlson

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  1. Henry L. Schreiber
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  2. W. Gibson Wood
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  3. Richard H. Carlson
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Schreiber, H.L., Gibson Wood, W. & Carlson, R.H. Tolerance in methylphenidate-induced locomotion in prairie dogs (cynomys ludovicianus). Psychopharmacologia 46, 111–113 (1976). https://doi.org/10.1007/BF00421557

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  • DOI: https://doi.org/10.1007/BF00421557

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