Abstract
Fingerling rainbow trout (N=436) were trained in one trial with brief electric shock (2.0 V/cm) to suppress their spontaneous upstream swimming into a quiet well. Memory retention one day later was not influenced by the temperature at which they had been acclimated, trained and tested (10‡ C, 15‡ C or 20‡ C). When exposed 4 min after training for 2 min, to a flurothyl solution (10, 25, 50, 100 or 200 Μl/l) trout convulsed and overturned. The onset of overturn was concentration- and temperature-dependent. Flurothyl altered the one-day retention of avoidance behavior; low concentrations enhanced, whereas high concentrations impaired. Memory-enhancing low concentrations of flurothyl, applied after post-training amnesic treatment with carbon dioxide, reversed the carbon dioxide amnesia.
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References
Agranoff, B. W.: Further studies on memory formation in the goldfish. In: The chemistry of mood, motivation, and memory (J. L. McGaugh, ed.) pp. 175–185. New York: Plenum Press 1972
Albert, D. J.: The effects of polarizing currents on the consolidation of learning. Neuropsychologia 4, 65–77 (1966)
Alpern, H. P., Kimble, D. P.: Retrograde amnesic effects of diethyl ether and bis (trifluoroethyl) ether. J. comp. physiol. Psychol. 63, 168–171 (1967)
Barondes, S. H., Cohen, H. D.: Arousal and the conversion of “short-term” to “long-term” memory. Proc. nat. Acad. Sci. (Wash.) 61, 923–929 (1968)
Boggan, W. O., Schlesinger, K.: Pharmacological correlates of ECS induced disruption of a passive avoidance task in mice. Behav. Biol. 12, 127–134 (1974)
Bohdanecky, Z., Kopp, R., Jarvik, M. E.: Comparison of ECS and flurothyl-induced retrograde amnesia in mice. Psychopharmacologia (Berl.) 12, 91–95 (1968)
Cherkin, A.: Flurothyl toxicity: a remarkable species difference between chick and mouse. Psychopharmacologia (Berl.) 15, 404–407 (1969a)
Cherkin, A.: Kinetics of memory consolidation: role of amnesic treatment parameters. Proc. nat. Acad. Sci. (Wash.) 63, 1094–1101 (1969b)
Cherkin, A., Catchpool, J. F.: Temperature dependence of anesthesia in goldfish. Science 144, 1460–1462 (1964)
Cherkin, A., Meinecke, R. O., Garman, M. W.: Retrograde enhancement of memory by mild flurothyl treatment in the chick. Physiol. Behav. 14, 1–8 (1975)
Crabbe, J. C., Alpern, H. P.: Facilitation and disruption of long-term store of memory with neural excitants. Pharmacol. Biochem. Behav. 1, 197–202 (1973)
Davis, R. E., Bright, P. J., Agranoff, B. W.: Effect of ECS and puromycin on memory of fish. J. comp. physiol. Psychol. 60, 162–166 (1965)
Denti, A., McGaugh, J. L., Landfield, P. W., Shinkman, P.: Effects of post-trial electrical stimulation of the mesencephalic reticular formation on avoidance learning in rats. Physiol. Behav. 5, 659–662 (1970)
Destrade, C., Soumireu-Mourat, B., Cardo, B.: Effects of post-trial hippocampal stimulation on acquisition. Behav. Biol. 8, 713–724 (1973)
Duncan, N., Hunt, E.: Reduction of ECS-produced retrograde amnesia by post-trial introduction of strychnine. Physiol. Behav. 9, 295–300 (1972)
Frank, L. H., Meyer, M. E.: Activity in rainbow trout (Salmo gairdneri) as a function of acclimation and thermal environment. Psychon. Sci. 23, 377–378 (1971)
Hunn, J. B., Allen, J. L.: Movement of drugs across the gills of fishes. Ann. Rev. Pharmacol. 14, 47–55 (1974)
Laurell, B.: Flurothyl convulsive therapy. Acta psychiat. scand., Suppl. 213 (1970)
Litchfield, J. T., Wilcoxon, F.: A simplified method for evaluating dose-effect experiments. J. Pharmacol. exp. Ther. 96, 99–113 (1949)
Liu, Y., Braud, W. G.: Modification of learning and memory in goldfish through the use of stimulant and depressant drugs. Psychopharmacologia (Berl.) 35, 99–112 (1974)
McGaugh, J. L., Gold, P. E.: The effects of drugs and electrical stimulation of the brain on memory storage processes. In: Neurohumoral coding of brain function, R. D. Myers and R. R. Drucker-Colin, eds. New York: Plenum Press 1974
McGaugh, J. L., Herz, M. J., eds.: Memory consolidation. San Francisco: Albion 1972
McGaugh, J. L., Zornetzer, S. F.: Amnesia and brain seizure activity in mice: effects of diethyl ether anesthesia prior to electroshock stimulation. Behav. Biol. 5, 243–248 (1971)
Mrosovsky, N.: Temperature and learning in poikilotherms. J. theor. Biol. 39, 659–663 (1973)
Neale, J. H., Klinger, P. D., Agranoff, B. W.: Temperature-dependent consolidation of puromycin-susceptible memory in goldfish. Behav. Biol. 9, 267–278 (1973)
Nigrelli, R. F.: The fish in biological research. N. Y. Acad. Sci. 15, 183–186 (1953)
Ravin, M. B., Tham, M. K.: The goldfish as an anesthesia and resuscitation teaching model. Anesthesiology 40, 288–290 (1974)
Riege, W. H., Cherkin, A.: One-trial learning in goldfish: temperature dependence. Behav. Biol. 7, 255–263 (1972)
Riege, W. H., Cherkin, A.: Retroactive facilitation of memory in goldfish by flurothyl. Psychopharmacologia (Berl.) 30, 195–204 (1973)
Riege, W. H., Cherkin, A.: Sensitive period for reversal of carbon-dioxide amnesia in goldfish. Behav. Biol. 12, 477–490 (1974)
Schuck, S. L., Shulman, A.: A study of the central action of flurothyl and methoxyflurane. Aust. J. exp. Biol. med. Sci. 49, 501–512 (1971)
Stevens, T. D., Randall, D. J.: Changes of gas concentrations in blood and water during moderate swimming activity in rainbow trout. J. exp. Biol. 46, 329–337 (1967)
Zornetzer, S., McGaugh, J. L.: Retrograde amnesia and brain seizures in mice. Physiol. Behav. 7, 401–408 (1971)
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Supported by the Veterans Administration under Project 1387-01 and by NIMH Small Grant 24346-01 to WHR.
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Riege, W.H., Cherkin, A. Memory performance after flurothyl treatment in rainbow trout. Psychopharmacologia 46, 31–35 (1976). https://doi.org/10.1007/BF00421546
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DOI: https://doi.org/10.1007/BF00421546