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The effects of benzodiazepines on aggression: Reduced or increased?

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  • Human Pharmacology
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Abstract

The effects of various benzodiazepines on animal models of aggression are presented. The differences in response noted after single dose or after chronic drug administrations are stressed. The implications for predicting responses to these drugs in humans are discussed.

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References

  • Bauen, A., Possanza, G. J.: The mink as a psychopharmacological model. Arch. int. Pharmacodyn. 186, 133–136 (1970).

    Google Scholar 

  • Boissier, J. R., Simon, P., Aron, C.: A new method for rapid screening of minor tranquilizers in mice. Europ. J. Pharmacol. 4, 145–151 (1968).

    Google Scholar 

  • Boyle, D., Tobin, J.: Pharmaceutical management of behavior disorders. J. med. Soc. N. J. 58, 427–429 (1961).

    Google Scholar 

  • Brady, J. V., Nauta, W. J. H.: Subcortical mechanisms in emotional behavior; affective changes following septal forebrain lesion in the albino rat. J. Comp. physiol. Psychol. 46, 339–346 (1953).

    Google Scholar 

  • Christmas, A. J., Maxwell, D. R.: A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 9, 17–29 (1970).

    Google Scholar 

  • Cole, H. F., Wolf. H. H.: Laboratory evaluation of aggressive behavior of the grasshopper mouse (Onychomys). J. Pharm. Sci. 59, 969–971 (1970).

    Google Scholar 

  • Dimascio, A., Shader, R. I., Giller, D. R.: Behavioral toxicity: Part III: perceptualcognitive functions and Part IV: Emotional (mood) states, in Psychotropic Drug Side Effects. R. I. Shader and A. Dimascio, eds., pp. 132–141. Baltimore: Williams & Wilkins 1970.

    Google Scholar 

  • Dimascio, A., Shader, R. I., Harmatz, J. S.: Psychotropic drugs and induced hostility. Psychosomatics 10, 46–47 (1969).

    Google Scholar 

  • Feldman, P. E.: An analysis of the efficacy of diazepam. J. Neuropsychiat. (Suppl.) 3, S62-S67 (1962).

    Google Scholar 

  • Fox, K. A., Snyder, R. L.: Effect of sustained low doses of diazepam on aggression and mortality in grouped male mice. J. comp. physiol. Psychol. 69, 663–666 (1969).

    Google Scholar 

  • Fox, K. A., Tockosh, J. R., Wolcox, A. H.: Increased aggression among group male mice fed chlordiazepoxide. Europ. J. Pharmacol. 11, 119–121 (1970).

    Google Scholar 

  • Fox, K. A.: Personal Communication, October 1971.

  • Fox, K. A., Webster, J. C., Guerriero, F. J.: Increased aggression among grouped male mice fed nitrazepam and flurazepam. Europ. J. Pharmacol. (in press).

  • Gardos, G., Dimascio, A., Salzman, C., Shader, R. I.: Differential actions of chlordiazepoxide and oxazepam on hostility. Arch. gen. Psychiat. 18, 757–760 (1968).

    Google Scholar 

  • Gleser, G. C., Gottschalk, L. A., Fox, R., Lippert, W.: Immediate changes in affect with chlordiazepoxide. Arch. gen. Psychiat. 13, 291–295 (1965).

    Google Scholar 

  • Guaitani, A., Marcucci, F., Garanttini, S.: Increased aggression and toxicity in grouped male mice treated with tranquilizing benzodiazepines. Psychopharmacologia (Berl.) 19, 241–245 (1971).

    Google Scholar 

  • Heise, G. A., Boff, E.: Taming action of chlordiazepoxide. Fed. Proc. 20, 393 (1961).

    Google Scholar 

  • Heuschele, W. P.: Chlordiazepoxide for calming zoo animals. J. Amer. vet. med. Ass. 139, 996 (1961).

    Google Scholar 

  • Hoffmeister, F., Wuttke, W.: On the actions of psychotropic drugs on the attack- and aggressive-defensive behaviour of mice and cats, in Aggressive Behavior. S. Garratini and B. Sigg. eds., pp. 273–280. New York: Wiley 1969.

    Google Scholar 

  • Horowitz, Z. P., Furgiuele, A. R., Brannick, L. J., Burke, J. C., Craver, B. N.: A new chemical structure with specific depressant effects on the amygdala and on the hyperirritability of the “septal rat” Nature (Lond.) 200, 269 (1963).

    Google Scholar 

  • Kalina, R. K.: Diazepam: its role in a prison setting. Dis. nerv. Syst. 25, 101 (1964).

    Google Scholar 

  • Kelley, J. W., Gisvold, D. I.: The use of MMPI in the evaluation of Librium. Colo. G. P. 2, 3–8 (1960).

    Google Scholar 

  • Kostowski, W.: A note on the effects of some psychotropic drugs on the aggressive behaviour in the ant. Formica rufa. J. Pharm. Pharmacol. 18, 747–749 (1966).

    Google Scholar 

  • Langfeldt, T., Ursin, H.: Differential action of diazepam on flight and defense behavior in the cat. Psychopharmacologia (Berl.) 19, 61–66 (1971).

    Google Scholar 

  • Mercier, J., Dessaigne, S.: Influence exercée par quelques drogues psycholeptiques sur le comportement du scorpion (Androctonus australis Hector). C. R. Soc. Biol. (Paris) 164, 341–344 (1970).

    Google Scholar 

  • Morpurgo, C.: Aggressive behavior induced by large doses of 2-(2,6-dichlorophenyl-amino)-2-imindazoline hydrochloride (ST 155) in mice. Europ. J. Pharmacol. 3, 373–377 (1968).

    Google Scholar 

  • Podobnikar, I. G.: Implementation of psychotherapy in Librium in a pioneering rural-industrial psychiatric practice. Psychosomatics 12, 205–209 (1971).

    Google Scholar 

  • Podvalova, I., Dlabac, A., Votava, Z.: Mesorgydine-induced aggressive behavior in rats. Intern. Congr. Pharmacol. (Pamphlet) 4th, Basle, pp. 297–298 (1969).

  • Randall, L. O.: Pharmacology of methaminodiazepoxide. Dis. nerv. Syst. (Suppl.) 21, 7–10 (1960).

    Google Scholar 

  • Randall, L. O.: Pharmacology of chlordiazepoxide. Dis. nerv. Syst. (Suppl.) 22, 7–15 (1961).

    Google Scholar 

  • Rickels, K.: Personal Communication, October 1971.

  • Salzman, C., Dimascio, A., Shader, R. I., Harmatz, J. S.: Chlordiazepoxide, expectation and hostility. Psychopharmacologia (Berl.) 14, 38–45 (1969).

    Google Scholar 

  • Scheckel, C. L., Boff, E.: Effects of drugs on aggressive behavior in monkeys, in Neuro-Psychopharmacology V. Proceedings of the Fifth Meeting of the Collegium Internationale Neuro-Psychopharmacologicum. H. Brill, J. O. Cole, P. Deniker, et al., eds., pp. 789–795. Excerpta Medica Series No. 129, Amsterdam 1967.

  • Senault, B.: Comportement d'aggressivité intraspécifique induit par l'amporphine chez le rat. Psychopharmacologia (Berl.) 18, 271–287 (1970).

    Google Scholar 

  • Sofia, R. D.: Effects of centrally active drugs on four models of experimentally-induced aggression in rodents. Life Sci. 8, 705–716 (1969).

    Google Scholar 

  • Tedeschi, R. E., Tedeschi, D. H., Mucha, A., Cook, L., Mattis, P. A., Fellows, E. J.: Effects of various centrally acting drugs on fighting behavior of mice. J. Pharmacol. exp. Ther. 125, 28–34 (1959).

    Google Scholar 

  • Yen, H. C. Y., Stanger, R. L., Millman, N.: Isolation-induced aggressive behavior in ataratic tests. J. Pharmacol. exp. Ther. 122, 85A (1958).

    Google Scholar 

  • Yen, H. C. Y., Katz, M. H., Krop, S.: Effects of various drugs an 3,4-dihidroxyphenylalanine (dl-DOPA) induced excitation (aggressive behavior) in mice. Toxicol. appl. Pharmacol. 17, 597–604 (1970).

    Google Scholar 

  • Valzelli, L., Giacalone, E., Garattini, S.: Pharmacological control of aggressive behavior in mice. Europ. J. Pharmacol. 2, 144–146 (1967).

    Google Scholar 

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DiMascio, A. The effects of benzodiazepines on aggression: Reduced or increased?. Psychopharmacologia 30, 95–102 (1973). https://doi.org/10.1007/BF00421423

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