Advertisement

Psychopharmacologia

, Volume 46, Issue 2, pp 179–183 | Cite as

Intracranial self-stimulation in rats as a function of various stimulus parameters

VI. Influence of fentanyl, piritramide, and morphine on medial forebrain bundle stimulation with monopolar electrodes
  • Albert Wauquier
  • Carlos J. E. Niemegeers
Animal Studies

Abstract

The effects of different subcutaneous doses of fentanyl (0.02, 0.04, 0.08, and 0.16 mg/kg), piritramide (0.63, 2.50, 10.0, and 40.0 mg/kg), and morphine (2.50, 5.00, 10.0, and 20.0 mg/kg) on self-stimulation in rats were studied. Different stimulus parameter combinations (SPC) inducing low, high, or intermediate control response rates (CRR) were applied during the same experimental sessions. The three narcotic analgesics induced response depression (RD) and response stimulation (RS). RS was mostly observed at low dose levels; RD was dose-related. SPC's inducing low CRR were more sensitive than those inducing high CRR. Fentanyl was more potent than piritramide and than morphine. The RD is related to motor incapacitation, as the doses needed to effectively reduce self-stimulation also induced obvious catatonia. The RS probably is a more specific effect reflecting sensitization of structures involved in reinforcement of behavior.

Key words

Fentanyl Piritramide Morphine Catatonia Self-stimulation Medial forebrain bundle Stimulus parameter combinations 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, W. I., Lorens, S. A., Mitchell, C. L.: Morphine enhances lateral hypothalamic self-stimulation in the rat. Proc. Soc. exp. Biol. (N.Y.) 140, 770–771 (1972)Google Scholar
  2. Andén, N. E., Bédard, P.: Influence of cholinergic mechanisms on the function and turnover of brain dopamine. J. Pharm. Pharmacol. 23, 460–462 (1971)Google Scholar
  3. Andén, N. E., Butcher, S. O., Corrodi, H., Fuxe, K., Ungerstedt, U.: Receptor activity and turnover of dopamine and noradrenaline after neuroleptics. Europ. J. Pharmacol. 11, 303–314 (1970)Google Scholar
  4. Bowers, M. B., Roth, R. H.: Interaction of atropine-like drugs with dopamine-containing neurones in rat brain. Brit. J. Pharmacol. 44, 301–306 (1972)Google Scholar
  5. Domino, E. F.: Personal communication (1974)Google Scholar
  6. Fuxe, K., Ungerstedt, U.: Histochemical, biochemical and functional studies on central monoamine neurons after acute and chronic amphetamine administration. In: Amphetamine and related compounds, E. Costa and S. Garattini, eds., pp. 257–288. New York: Raven Press 1970Google Scholar
  7. Geivers, H. A., Xhonneux, R., Wauquier, A., Van Nueten, J., Reneman, R.: Programmable stimulator for biomedical research. Ann. Biomed. Eng. 3, 12 (1973)Google Scholar
  8. Glick, S. D., Marcasanico, R. G., Zimmerberg, B., Charap, A. D.: Morphine dependence and self-stimulation: Attenuation of withdrawal-induced weight loss. Res. Commun. Chem. Path. Pharmacol. 5, 725–732 (1973)Google Scholar
  9. Janssen, P. A. J.: Piritramide (R 3365), a potent analgesic with unusual chemical structure. J. Pharmac. Pharmacol. 13, 513–530 (1961)Google Scholar
  10. Janssen, P. A. J., Niemegeers, C. J. E., Dony, J. G. H.: The inhibitory effect of fentanyl (R 4263) and other morphine-like analgesics on the warm water-induced tail withdrawal reflex in rats. Arzneimittel-Forsch. 13, 502–507 (1963)Google Scholar
  11. Kuschinsky, K., Hornykiewicz, O.: Morphine catalepsy in the rat: relation to striatal dopamine metabolism. Europ. J. Pharmacol. 19, 119–122 (1972)Google Scholar
  12. Kuschinsky, K., Hornykiewicz, O.: Effects of morphine on striatal dopamine metabolism: Possible mechanism of its opposite effect on locomotor activity in rats and mice. Europ. J. Pharmacol. 26, 41–50 (1974)Google Scholar
  13. Lorens, S. A., Mitchell, C. L.: Influence of morphine on lateral hypothalamic self-stimulation in the rat. Psychopharmacologia (Berl.) 32, 271–277 (1973)Google Scholar
  14. Marcus, R., Kornetsky, C.: Negative and positive intracranial reinforcement thresholds: Effects of morphine. Psychopharmacologia (Berl.) 38, 1–13 (1974)Google Scholar
  15. Olds, J.: Studies of neuropharmacologicals by electrical and chemical manipulation of the brain in animals with chronically implanted electrodes. In: Neuro-Psychopharmacology, B. P. Bradley, P. Deniker, C. Radoco-Thomas, eds., pp. 20–32. Amsterdam: Elsevier 1959Google Scholar
  16. Olds, J., Travis, R. P.: Effects of chlorpromazine, meprobamate, pentobarbital and morphine on self-stimulation. J. Pharmacol. exp. Ther. 128, 397–404 (1960)Google Scholar
  17. Sasame, H. A., Perez-Cruet, J., Di Chiara, G., Tagliamonte, A., Tagliamonte, P., Gessa, G. L.: Evidence that methadone blocks dopamine receptors in brain. J. Neurochem. 19, 1953–1957 (1972)Google Scholar
  18. Scheel-Krüger, J.: On the possible interrelationship in mechanism of action between morphine, amphetamine and neuroleptic drugs. In Frontiers in catecholamine research, E. Usdin, S. H. Snyder, eds., pp. 1027–1029. New York: Pergamon Press 1973Google Scholar
  19. van Rossum, J. M., Pijnenburg, A. J. J., Cools, A. R., Broekkamp, C., Struyker, Boudier, H. A. J.: Behavioural pharmacology of the nigrostriatal and mesolimbic system. IXth Congress of the CINP, Paris. J. Pharmacol. (Paris) 5, Suppl. 1, 62 (1974)Google Scholar
  20. Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. II. The influence of haloperidol, pimozide and pipamperone on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 27, 191–202 (1972)Google Scholar
  21. Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. III. The influence of apomorphine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 30, 163–172 (1973)Google Scholar
  22. Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. IV. The influence of amphetamine on medial forebrain bundle stimulation with monopolar electrode. Psychopharmacologia (Berl.) 34, 265–274 (1974a)Google Scholar
  23. Wauquier, A., Niemegeers, C. J. E.: Intracranial self-stimulation in rats as a function of various stimulus parameters. V. The influence of cocaine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia (Berl.) 38, 201–210 (1974b)Google Scholar
  24. Wauquier, A., Niemegeers, C. J. E., Lal, H.: Differential antagonism by naloxone of inhibitory effects of haloperidol and morphine on brain self-stimulation. Psychopharmacologia (Berl.) 37, 303–310 (1974)Google Scholar
  25. Wauquier, A., Niemegeers, C. J. E., Lal, H.: Differential antagonism by dexetimide of inhibitory effects of haloperidol and fentanyl on brain self-stimulation. Psychopharmacologia (Berl.) 41, 229–235 (1975)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Albert Wauquier
    • 1
  • Carlos J. E. Niemegeers
    • 1
  1. 1.Department of Pharmacology, Janssen PharmaceuticaResearch LaboratoriesBeerseBelgium

Personalised recommendations