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Psychopharmacologia

, Volume 46, Issue 2, pp 167–168 | Cite as

Amantadine: Effet agressogéne propre ; effet sur l'agressivité induite par l'apomorphine chez le rat

  • B. Senault
Animal Studies

Amantadine: Aggressive effect; effect on apomorphine-induced aggressivity in the rat

Abstract

In rats characterized by aggressive behaviour induced by apomorphine, only amantadine in doses of 10 mg/kg i.v. and 50 mg/kg i.p. induces a very slight aggressive effect, but in doses of 30 and 50 mg/kg i.p. it inhibits the aggressive behaviour induced by 1 mg/kg apomorphine. The effect is dose-related and it is more pronounced when amantadine (50 mg/kg i.p.) is injected 30 min rather than 1 h before apomorphine.

Key words

Aggressive behaviour Apomorphine Amantadine 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. Senault
    • 1
  1. 1.Département de PharmacologieLaboratoire Le BrunAubervilliersFrance

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