, Volume 46, Issue 2, pp 167–168 | Cite as

Amantadine: Effet agressogéne propre ; effet sur l'agressivité induite par l'apomorphine chez le rat

  • B. Senault
Animal Studies

Amantadine: Aggressive effect; effect on apomorphine-induced aggressivity in the rat


In rats characterized by aggressive behaviour induced by apomorphine, only amantadine in doses of 10 mg/kg i.v. and 50 mg/kg i.p. induces a very slight aggressive effect, but in doses of 30 and 50 mg/kg i.p. it inhibits the aggressive behaviour induced by 1 mg/kg apomorphine. The effect is dose-related and it is more pronounced when amantadine (50 mg/kg i.p.) is injected 30 min rather than 1 h before apomorphine.

Key words

Aggressive behaviour Apomorphine Amantadine 


  1. Corrodi, H., Farnebo, L. O., Hamberger, B., Ungerstedt, U.: ET 495 and brain catecholamine mechanisms: Evidence for stimulation of dopamine receptors. Europ. J. Pharmacol. 20, 195–204 (1972)Google Scholar
  2. Corrodi, H., Fuxe, K., Ungerstedt, U.: Evidence for a new type of dopamine receptor stimulating agent. J. Pharm. Pharmacol. 23, 989–991 (1971)Google Scholar
  3. Cox, B., Tha, S. J.: Effects of amantadine and l-dopa on apomorphine- and d-amphetamine-induced stereotyped behaviour in rats. Europ. J. Pharmacol. 24, 96–100 (1973)Google Scholar
  4. Farnebo, L. O., Fuxe, K., Goldstein, M., Hamberger, B., Ungerstedt, U.: Dopamine and noradrenaline releasing action of amantadine in the central and peripheral nervous system: A possible mode of action in Parkinson's disease. Europ. J. Pharmacol. 16, 27–38 (1971)Google Scholar
  5. Maj, J., Sowinska, H., Baran, L.: The effect of amantadine on motor activity and catalepsy in rats. Psychopharmacologia (Berl.) 24, 296–307 (1972)Google Scholar
  6. Puech, A. J., Chermat, R., Goujet, M. A., Simon, P., Boissier, J. R.: Effets neuropsychopharmacologiques de cinq stimulants dopaminergiques centraux. J. Pharmacol. (Paris) 6, 209–220 (1975)Google Scholar
  7. Senault, B.: Comportement d'agressivité intraspécifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.) 18, 271–287 (1970)Google Scholar
  8. Senault, B.: Amines cérébrales et comportement d'agressivité intraspécifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.) 34, 143–154 (1974)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. Senault
    • 1
  1. 1.Département de PharmacologieLaboratoire Le BrunAubervilliersFrance

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