Reduction of alcohol selection by pargyline in mice
- 20 Downloads
Drugs which increase brain levels of serotonin (5-HT) have frequently been found to cause a decrease in voluntary ethanol consumption. Results obtained with parachlorophenylalanine (pCPA), which decreases 5-HT, have been less consistent. The present investigation compared the effects of pCPA on alcohol selection with those of pargyline, a monoamine oxidase inhibitor which increases brain levels of 5-HT. Ingestion of a 10% ethanol solution was assessed in male C57BL/6J mice given daily injections of 250 or 300 mg/kg pCPA, 50 mg/kg pargyline, or saline. An additional control group received no treatment. A two-bottle preference procedure was employed, and ethanol and water intake were recorded during a pretreatment period (11 days), a treatment period (8 days), and a posttreatment period (10 days). Like other agents which increase 5-HT, pargyline produced a depression in ethanol intake which lasted beyond the time of drug administration. pCPA had no effect on ethanol ingestion either during the period of drug administration or afterwards.
Key wordsAlcohol selection Pargyline Parachlorophenylalanine (pCPA) Serotonin
Unable to display preview. Download preview PDF.
- Cicero, T. J., Hill, S. Y.: Ethanol self selection in rats: A distinction between absolute and 95% ethanol. Physiol. Behav. 5, 787–791 (1970)Google Scholar
- Cohen, G., MacNamee, D., Dembiec, D.: Elevation in blood acetaldehyde by pargyline during ethanol administration. Biochem. Pharmacol. 24, 313–316 (1975)Google Scholar
- Erwin, V. G., Deitrich, R. A.: The labeling in vivo of monoamine oxidase by 14C-pargyline: A tool for studying the synthesis of the enzyme. Molec. Pharmacol. 7, 219–228 (1971)Google Scholar
- Frey, H. H., Magnussen, M. P., Nielsen, Chr. K.: The effects of p-chloramphetamine on the consumption of ethanol by rats. Arch. int. Pharmacodyn. 183, 165–172 (1970)Google Scholar
- Geller, I.: Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat. Pharmacol. Biochem. Behav. 1, 361–365 (1973)Google Scholar
- Hill, S. Y.: Intraventricular injection of 5-hydroxytryptamine and alcohol consumption in rats. Biol. Psychiat. 8, 151–158 (1974)Google Scholar
- Myers, R. D., Evans, J. E., Yaksh, T. L.: Ethanol preference in the rat: Interactions between brain serotonin and ethanol, acetaldehyde, paraldehyde, 5-HTP, and 5-HTOL. Neuropharmacology 11, 539–549 (1972)Google Scholar
- Nachman, M., Lester, D., LeMagnen, J.: Alcohol aversion in the rat. Behavioral assessment of noxious drug effects. Science 168, 1244–1245 (1970)Google Scholar
- Pellegrino de Iraldi, A., Zieher, L. M., De Roberts, E.: The 5-hydroxytryptamine content and synthesis of normal and denervated pineal gland. Life Sci. 9, 691–696 (1963)Google Scholar
- Rodgers, D. A., McClearn, G. E.: Mouse strain differences in preference for various concentrations of alcohol. Quart. J. Stud. Alcohol 23, 26–33 (1962)Google Scholar
- Veale, W. L., Myers, R. D.: Decrease in ethanol intake in rats following administration of p-chlorophenylalanine. Neuropharmacology 9, 317–326 (1970)Google Scholar