Psychopharmacologia

, Volume 46, Issue 2, pp 123–126 | Cite as

Euflavine: Effect on brain heavy metal content and staining pattern, and on shuttle box behavior in goldfish

  • K. Tetsche
  • E. J. Fjerdingstad
  • Erik Fjerdingstad
Original Investigations Laboratory Studies

Abstract

Goldfish were exposed to euflavine in doses of 7–100 mg/l for 1 h–14 days. The treatment resulted in a reduced stainability of the brain with the Timm histochemical procedure for ‘heavy metals’. In contrast, analysis by flameless atomic absorption spectrophotometry showed no significant changes in the concentrations of zinc and of copper after euflavine treatment. In the shuttle box a significant increase in general activity was found. These results, compared to earlier work with other chelating agents, indicate that such drugs do not have a uniform effect on behavior, and that they do not cause a true depletion of heavy metals in the brain.

Key words

Euflavine Brain Heavy metals Behavior Goldfish Shuttle box Learning Memory 

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • K. Tetsche
    • 1
  • E. J. Fjerdingstad
    • 1
  • Erik Fjerdingstad
    • 2
  1. 1.Department of AnatomyUniversity of AarhusDenmark
  2. 2.Department of HygieneUniversity of CopenhagenDenmark

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