Abstract
Psychoactive doses (0.7 mg/kg) of the hallucinogen N,N-dimethyltryptamine (DMT) were administered intramuscularly to 11 normal subjects. A gas chromatographic-mass spectrometric isotope dilution determination of DMT concentrations in whole blood and urine revealed that only a fraction of the injected dose was recovered and the blood DMT concentrations had a very similar time course o the subjectively reported “high”.
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References
Arnold, O. H., Hofman, G.: Zur Psychopathologie des Dimethyltryptamin: Ein weiterer Beitrag zur Pharmakopsychiatrie. Wien. Z. Nervenheilk. 13, 438–445 (1957)
Bidder, T. G., Mandel L. R., Ahn, H. W., Walker, R. W., VandenHeuvel, W. J. A.: Blood and urinary DMT concentrations in acute psychotic disorders. Lancet (in press)
Cohen, I., Vogel, W. H.: Determination and physiological disposition of dimethyltryptamine and diethyltryptamine in rat brain, liver, and plasma. Biochem. Pharmacol. 21, 1214–1216 (1972)
Franzen, F., Gross, H.: Tryptamine, N,N-dimethyltryptamine, N,N-dimethyl-5-hydroxytryptamine and 5-methoxytryptamine in human blood and urine. Nature (Lond.) 206, 1052 (1965)
Lipinski, J., Mandel, L. R., Ahn, H. S., VandenHeuvel, W. J. A., Walker, R. W.: Blood dimethyltryptamine concentrations in psychotic disorders. Biol. Psychiat. (in press)
Mandel, L. R., Ahn, H. S., VandenHeuvel, W. J. A., Walker, R. W.: Indoleamine-N-methyl transferase in human lung. Biochem. Pharmacol. 21, 1197 to 1200 (1972)
Mandell, A. J., Morgan, M.: Indole(ethyl)amine N-methyltransferase in human brain. Nature New Biol. 230, 85–87 (1971)
Narasimhachari, N., Avalos, J., Fujimori, M., Himwich, H. E.: Studies of drug-free schizophrenics and controls. Biol. Psychiat. 5, 311–318 (1972)
Narasimhachari, N., Heller, B., Spaide, J., Haskovec, L., Meltzer, H., Strahilevitz, M., Himwhich, H. E.: N,N-dimethylated indoleamines in blood. Biol. Psychiat. 3, 21–23 (1971)
Rosenberg, D. E., Isbell, H., Miner, E. J.: Comparison of a placebo, N-dimethyl-tryptamine, and 6-hydroxy-N-dimethyltryptamine in man. Psychophamacologia (Berl.) 4, 39–42 (1963)
Rosengarten, H., Szemis, A., Piotrowski, A., Roamszewska, K., Matsumoto, H., Stencka, K., Jus, A.: N,N-dimethyltryptamine and bufotenine in the urine of patients with chronic and acute schizophrenic psychosis. Psychiat. Polska 4, 519–521 (1970)
Saavedra, J. M., Axelrod, J.: Psychotomimetic N-methylated tryptamine: formation in brain in vivo and in vitro. Science 24, 1365–1366 (1972)
Sai-Halasz, A.: The effect of antiserotonin on the experimental psychosis induced by dimethyltryptamine. Experientia (Basel) 18, 137–138 (1962)
Sai-Halasz, A., Brunecker, G., Szara, S.: Dimethyltryptamine: Ein neues Psychoticum. Psychiat. et Neurol. (Basel) 135, 285–301 (1958)
Szara, S.: Dimethyltryptamine—its metabolism in man; the relation of its psychotic effect to the serotonin metabolism. Experientia (Basel) 12, 441–442 (1956)
Tanimukai, H., Ginter, R., Spaide, J., Bueno, J. R., Himwich, H. E.: Detection of psychotomimetic N,N-dimethylated indoleamines in the urine of four schizophrenic patients. Brit. J. Psychiat. 117, 421–430 (1970)
Walker, R. W., Ahn, H. S., Albers-Schonberg, G., Mandel, L. R., VandenHeuvel, W. J.: Gas chromatographic-mass spectrometric isotope dilution assay for N,N-dimethyltryptamine in human plasma. Biochem. Med. 8, 105 (1973)
Walker, R. W., Ahn, H. S., Mandel, L. R., VandenHeuvel, W. J. A.: Identification of N,N-dimethyltryptamine as the product of an in vitro enzymatic methylation. Analyt. Biochem. 47, 228–234 (1972)
Wyatt, R. J., Gillin, J. C., Kaplan, J., Stillman, R., Mandel, L., Ahn, H. S., VandenHeuvel, W. J. A., Walker, R. W.: N,N-Dimethyltryptamine—A possible relationship to schizophrenia? In: Serotonin—New Vistas. E. Costa, G. L. Gessa, and M. Sandler, Eds., vol. 11. New York: Raven Press 1974
Wyatt, R. J., Mandel, L. R., Ahn, H. S., Walker, R. W., VandenHeuvel, W. J. A.: Gas-chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients. Psychopharmacologia (Berl.) 31, 265–270 (1973)
Wyatt, R. J., Saavedra, J. M., Axelrod, J.: A dimethyltryptamine (DMT) forming enzyme in human blood. Amer. J. Psychiat. 130, 754–760 (1973)
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Kaplan, J., Mandel, L.R., Stillman, R. et al. Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects. Psychopharmacologia 38, 239–245 (1974). https://doi.org/10.1007/BF00421376
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DOI: https://doi.org/10.1007/BF00421376