Abstract
The activity of circulatory dopamine-Β-hydroxylase (DBH) in humans is shown to be lower in some epileptic subjects than in normal subjects. The activity of the enzymes was found to be dramatically low in subjects who experienced an epileptic seizure 24 hrs before DBH activity was determined. The activity varied through the course of epileptic seizures induced by a convulsant drug and these variations might be due to the “en masse” changes of the sympathetic nervous system.
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Abbreviations
- DBH:
-
Dopamine-Β-hydroxylase
- Bemegride:
-
4-methyl-4-ethyl-2,6-dioxopiperidine
References
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This work is a part of the Doctorat d'Université Thésis of M.T. M.-P., recipient of the Juan March Fundation.
D.A. is Attaché de Recherche at the INSERM.
Service d'Exploration fonctionelle du Système Nerveux.
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Miras-Portugal, M.T., Aunis, D., Mandel, P. et al. Human circulating dopamine-Β-hydroxylase and epilepsy. Psychopharmacologia 41, 75–79 (1975). https://doi.org/10.1007/BF00421310
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DOI: https://doi.org/10.1007/BF00421310