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Effect of lithium on central metabolism of 5-hydroxytryptamine

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Abstract

The administration of lithium carbonate for 5 days to rats increased the synthesis rate of brain serotonin, without modifying the brain level of the amine. This increase was not due to a modification of the free tryptophan in the blood. The level of serotonin and 5 HIAA remained unchanged in seven areas of brain. These results are discussed in comparison with the results of the other authors on the same subject.

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References

  • Andreoli, V. M., Frigeni, V., Napoli, P. A.: Effetto del litio sulla serotonina cerebrale e piastrinica. Boll. Soc. ital. Biol. sper. 44, 1904–1906 (1968)

    Google Scholar 

  • Bliss, E. L., Allion, J.: The effect of lithium upon brain neuroamines. Brain Res. 24, 305–310 (1970)

    Google Scholar 

  • Cade, J. F. J.: Lithium salts in the treatment of psychotic excitement. Med. J. Aust. 36, 349–352 (1949)

    Google Scholar 

  • Corrodi, H., Fuxe, K., Schou, M.: The effect of prolonged lithium administration on cerebral monoamine neurons in the rat. Life Sci. 8, 643–651 (1959)

    Google Scholar 

  • Curzon, G., Green, A. R.: Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regious of rat brain. Brit. J. Pharmacol. 39, 653–655 (1970)

    Google Scholar 

  • Curzon, G., Joseph, M. H., Knott, P. J.: Effects of immobilization and food deprivation on rat brain tryptophan metabolism. J. Neurochem. 19, 1967–1974 (1972)

    Google Scholar 

  • Genefke, I. K.: The concentration of 5-HT in hypothalamus, grey and white brain substance in the rat after prolonged oral lithium administration. Acta psychiat. scand. 48, 400–404 (1972)

    Google Scholar 

  • Guerinot, F., Poitou, P., Bohuon, C.: Serotonin synthesis in the rat brain after acetylsalicylic acid administration. J. Neurochem. 22, 191–192 (1974)

    Google Scholar 

  • Hess, S. M., Udenfriend, S. M.: A fluorometric procedure for the measurement of tryptamine in tissue. J. Pharmacol. exp. Ther. 127, 175–177 (1969)

    Google Scholar 

  • Ho, A. K. S., Loh, H. H., Craves, F., Hitzeman, R. J., Gershon, S.: The effect of prolonged lithium treatment on the synthesis rat and turn-over of monoamines in brain regions of rats. Europ. J. Pharmac. 10, 72–78 (1970)

    Google Scholar 

  • Knapp, S., Mandell, A. J.: Short and long term lithium administration: effects on the brain's serotonergic biosynthetic system. Science 180, 645–647 (1973)

    Google Scholar 

  • Mendels, J., Chernik, D. A.: The effects of lithium carbonate on the sleep of depressed patients. Int. Pharmacopsychiat. 8, 184–192 (1973)

    Google Scholar 

  • Perez-cruet, J., Tagliamonte, A., Tagliamonte, P., Gessa, G. L.: Stimulation of serotonin synthesis by lithium. J. Pharmacol. exp. Ther. 178, 325–330 (1971)

    Google Scholar 

  • Poitou, P.: Modifications biochimiques cérébrales dues à l'administration des sels de lithium. Path. et Biol. 22, 163–171 (1974a)

    Google Scholar 

  • Poitou, P., Boulu, R., Bohuon, C.: Action du lithium sur l'hyperactivité de la souris provoquée par l'injection d'un mélange chlordiazepoxide-amphétamine. Experientia (Basel) (in press) (1974b)

  • Schou, M., Shaw, D. M.: Lithium in recurrent manic depressive disorders. Practitioner 210, 105–111 (1973)

    Google Scholar 

  • Schubert, J.: Effect of chronic lithium treatment on monoamine metabolism in rat brain. Psychopharmacologia (Berl.) 32, 301–311 (1973)

    Google Scholar 

  • Sheard, M. H., Aghajanian, G. K.: Neuronally activated metabolism of brain serotonin: effect of lithium. Life Sci. 9, 285–290 (1970)

    Google Scholar 

  • Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., Gessa, G. L.: Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nature New Biol. 229, 125–126 (1971a)

    Google Scholar 

  • Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., Stern, S.: Effect of psychotropic drugs on tryptophan concentration in the rat brain. J. Pharmacol. exp. Ther. 177, 475–480 (1971b)

    Google Scholar 

  • Tozer, T. N., Neff, N. H., Brodue, B. B.: Application of steady state kinetics to the synthesis rate and turn-over time of serotonin in the brain of normal and reserpine treated rats. J. Pharmacol. exp. Ther. 153, 177–182 (1966)

    Google Scholar 

  • Wilson, I. C., Prange, A. J.: Tryptophan in mania: theory of affective disorders. Psychopharmacologia (Berl.) 26, Suppl. 76 (1972)

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Biologie Clinique et Expérimentale Institut Gustave-Roussy, Villejuif, France

    P. Poitou, F. Guerinot & C. Bohuon

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  1. P. Poitou
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  2. F. Guerinot
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  3. C. Bohuon
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Poitou, P., Guerinot, F. & Bohuon, C. Effect of lithium on central metabolism of 5-hydroxytryptamine. Psychopharmacologia 38, 75–80 (1974). https://doi.org/10.1007/BF00421289

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  • DOI: https://doi.org/10.1007/BF00421289

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