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Effect of lithium on central metabolism of 5-hydroxytryptamine

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Abstract

The administration of lithium carbonate for 5 days to rats increased the synthesis rate of brain serotonin, without modifying the brain level of the amine. This increase was not due to a modification of the free tryptophan in the blood. The level of serotonin and 5 HIAA remained unchanged in seven areas of brain. These results are discussed in comparison with the results of the other authors on the same subject.

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Authors and Affiliations

  1. Laboratoire de Biologie Clinique et Expérimentale Institut Gustave-Roussy, Villejuif, France

    P. Poitou, F. Guerinot & C. Bohuon

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  1. P. Poitou
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  2. F. Guerinot
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  3. C. Bohuon
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Poitou, P., Guerinot, F. & Bohuon, C. Effect of lithium on central metabolism of 5-hydroxytryptamine. Psychopharmacologia 38, 75–80 (1974). https://doi.org/10.1007/BF00421289

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  • DOI: https://doi.org/10.1007/BF00421289

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