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Modifications by lithium of behavioral responses to methamphetamine and tetrabenazine

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Abstract

Different groups of mice were injected s.c. daily with lithium chloride in three doses (0.52, 1.58 and 4.72meq/kg) or with saline for a period of 3 weeks. Lithium administered acutely or chronically did not affect spontaneous locomotor activities. However, methamphetamine-induced hyper-locomotor activities were inhibited in the lithium groups as compared with those in the saline group, while the hyper-locomotor activities induced by tetrabenazine in the nialamide-pretreated animals were reduced to some extent but not significantly by lithium. Tetrabenazine brought about an initial transient increase followed by a decrease of spontaneous locomotor activities in the lithium groups, whereas it induced only a decrease of the activities in the saline group. In addition, jumping and vertical jumping behaviors, which were not observed in the saline group, occurred 30–60 min after tetrabenazine in the lithium groups. These effects of lithium tended to increase with an increase of the doses administered and with a prolongation of its daily administration. The results demonstrate that lithium modifies behavioral responses to methamphetamine and tetrabenazine.

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, Fukuoka University, Fukuoka, Japan

    Tatsuo Furukawa

  2. Department of Pharmacology, School of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

    Itsuko Ushizima & Nobufumi Ono

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  1. Tatsuo Furukawa
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  2. Itsuko Ushizima
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  3. Nobufumi Ono
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Furukawa, T., Ushizima, I. & Ono, N. Modifications by lithium of behavioral responses to methamphetamine and tetrabenazine. Psychopharmacologia 42, 243–248 (1975). https://doi.org/10.1007/BF00421263

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  • DOI: https://doi.org/10.1007/BF00421263

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