Abstract
The effects of chlordiazepoxide (CDP) on emergence behavior was examined in socially reared and isolation reared rats. It was found that low doses of CDP decreased the emergence times of isolated animals but had little effect on the emergence of social animals. At higher doses the drug retarded emergence in all groups but there were no differential effects. The results do not support claims that rearing conditions influence the susceptability of rats to CNS depressants, rather they suggest that particular levels of CDP selectively influence “emotional” behavior.
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References
Archer, J.: Sex differences in the emotional behavior of three strains of laboratory rat. Anim. Learn. Behav. 2, 43–48 (1974)
Baumel, I., De Fao, J. J., Lal, H.: Decreased potency of CNS depressants after prolonged isolation in mice. Psychopharmacologia (Berl.) 15, 153–158 (1969)
Broadhurst, P. L.: Determinants of emotionality in the rat. 1. Situational factors. Brit. J. Psychol. 48, 1–12 (1957)
Broadhurst, P. L.: The hereditary base for the actions of drugs on animal behaviour. In: Animal behaviour and drug action. H. Steinberg, A. V. S. de Reuck, and J. Knight, eds., pp. 224–236. London: Churchill 1974
Daly, M.: Early stimulation of rodents: a critical review of present interpretations. Brit. J. Psychol. 64, 435–460 (1973)
Gill, J. H., Reid, L. D., Porter, P. B.: Effects of restricted rearing on Lashley stand performance. Psychol. Rep. 19, 239–242 (1966)
Hughes, R. N., Syme, L. A.: The role of social isolation and sex in determining of effects of chlordiazepoxide and methylphenidate on exploratory behaviour. Psychopharmacologia (Berl.) 27, 359–366 (1972)
Irwin, S., Slabok, M., Thomas, G.: Individual differences: 1. Correlation between control locomotor activity and sensitivity to stimulant and depressant drags. J. Pharmacol. exp. Ther. 125, 206–211 (1958)
Lore, R. K., Levowitz, A.: Differential rearing and free versus forced exploration. Psychon. Sci. 5, 421–442 (1966)
Meyers, J. W.: Critical period for the facilitation of exploratory behavior by infantile experience. J. comp. physiol. Psychol. 55, 1099–1101 (1962)
Morgan, M. J.: Effects of post-weaning environment on learning in the rat. Anim. Behav. 21, 429–442 (1973)
Rushton, R., Steinberg, H.: Reactions to drugs influenced by early experience. Anim. Behav. 14, 585–586 (1966)
Syme, L. A.: Social isolation at weaning: Some effects on two measures of activity. Anim. Learn. Behav. 1, 161–163 (1973)
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Einon, D., Tye, N.C. Chlordiazepoxide and isolation induced timidity in rats. Psychopharmacologia 44, 83–85 (1975). https://doi.org/10.1007/BF00421188
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DOI: https://doi.org/10.1007/BF00421188