Abstract
Rats rendered chronically epileptic by the implantation of cobalt in the right parietal cortex were simultaneously prepared with permanent cortical and temporalis muscle electrodes for longitudinal EEG and EMG recording. Animals treated similarly with glass rods served as the controls. Wet dog shakes were quantified by counting the characteristic artifacts produced in the EEG tracings upon their appearance. The number of wet dog shakes exhibited by the control rats remained at a low and constant level over 18 days of recording. In contrast, wet dog shakes in the chronically epileptic rats began to increase by the fourth day after cobalt placement and remained significantly elevated up to the 18th day. Administration of reserpine to naive rats or to cobalt epileptic rats on days 7 and 9 after implantation resulted in an almost complete suppression of wet dog shakes which endured over a period of 3–5 days. These results suggest that the abnormally elevated wet dog shake response of the cobalt-epileptic rats and the spontaneous wet dog shake behavior of normal rats may be mediated by common neural pathways.
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Adler, M. W., Lin, C., Smith, K. P., Tresky, R., Gildenberg, P. L.: Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats. Psychopharmacologia (Berl.) 35, 243–247 (1974)
Colasanti, B. K., Craig, C. R.: Brain concentrations and synthesis rates of biogenic amines during chronic cobalt experimental epilepsy in the rat. Neuropharmacology 12, 221–231 (1973)
Colasanti, B. K., Hartman, E. R., Craig, C. R.: Electrocorticogram and behavioral correlates during the development of chronic cobalt experimental epilepsy in the rat. Epilepsia 15, 361–373 (1974)
Colasanti, B., Khazan, N.: Imipramine-induced changes in the rapid eye movement sleep rebound and wet dog shakes of morphine-abstinent rats. Neuropharmacology 14, 361–367 (1975)
Gold, M., Colasanti, B., Khazan, N.: Changes in behavior and REM sleep rebound of morphine abstinent rats during chronic imipramine treatment. Abstracts of the 5th International Congress on Pharmacology, San Francisco, p. 83 (1972)
Grimm, R. J., Frazee, J. C., Kawasaki, T., Savic, M.: Cobalt epilepsy in the squirrel monkey. Electroenceph. clin. Neurophysiol. 29, 525–528 (1970)
Henjyoji, E., Dow, R.: Cobalt-induced seizures in the cat. Electroenceph. clin. Neurophysiol. 19, 152–161 (1965)
Kopeloff, L. N.: Experimental epilepsy in the mouse. Proc. Soc. exp. Biol. (N.Y.) 104, 500–504 (1960)
Martin, W. R., Wikler, A., Eades, C. G., Pescor, F. T.: Tolerance to and physical dependence on morphine in rats. Psychopharmacologia (Berl.) 4, 247–260 (1963)
Schwartz, A. S., Eidelberg, E.: Role of biogenic amines in morphine dependence in the rat. Life Sci. 9, 613–624 (1970)
Wei, E., Loh, H. H., Way, E. L.: Neuroanatomical correlates of morphine dependence. Science 177, 616–617 (1972)
Wei, E., Loh, H. H., Way, E. L.: Quantitative aspects of precipitated abstinence in morphine-dependent rats. J. Pharmacol. exp. Ther. 184, 398–403 (1973a)
Wei, E., Loh, H. H., Way, E. L.: Neuroanatomical correlates of wet shake behavior in the rat. Life Sci. 12, 489–496 (1973b)
Wikler, A., Green, P. C., Smith, H. D., Pescor, F. T.: Use of a benzimidazole derivative with potent morphine-like properties orally as a presumptive reinforcer in conditioning of drug-seeking behavior in rats. Fed. Proc. 19, 22 (1960)
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A preliminary report on this work appeared in Pharmacologist 16, 325 (1974).
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Colasanti, B.K., Kosa, J.E. & Craig, C.R. Appearance of wet dog shake behavior during cobalt experimental epilepsy in the rat and its suppression by reserpine. Psychopharmacologia 44, 33–36 (1975). https://doi.org/10.1007/BF00421180
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DOI: https://doi.org/10.1007/BF00421180