Abstract
Six volunteer normal subjects, aged 18–25 years, were selected from a university student population to compare the psychotropic effects of Etifoxine, d-amphetamine and placebo. All of them received Etifoxine 300 mg, d-amphetamine 5 mg and placebo in a double-blind randomly crossover design involving a single dose weekly.
The criteria studied were the GSR and performance on the pursuit-rotor. The subjects were tested before (TO), 2 (T2) and 6 (T6) hrs after drug administration. At T2, both the GSR and pursuit-rotor performance obtained with each drug differed significantly from placebo, but not between drugs. The effects of Etifoxine were similar to those of d-amphetamine in reducing the GSR and improving pursuitrotor performance.
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Boissier, J. R., Simon, P., Zaczinska, M., Fichelle, J.: Etude psychopharmacologie expérimentale d'une nouvelle substante psychotrope, la 2-éthylamino-6-chloro-4-méthyl-4-phényl-4 H-3,1-benzoxazine. Thérapie 27, 325–333 (1972)
Córsico, R., Pastoriza, N. A., Dumon, A.: Psicotismo, extraversión y neurotismo. Estandarización de un inventario. (To be published 1975)
Eysenck, H. J.: Experiments with drugs. London: Oxford Pergamon Press 1963
Eysenck, S. B. G., Eysenck, H. J.: Scores on three personality variables as a function of age, sex and social class. Brit. J. Soc. clin. Psychol. 8, 69–76 (1969)
Galeano Muñoz, J.: Estudio comparativo del grupo benzodiacepínico. Actas ler. Congreso Luso-Brasileño de Psiquiatría, Belo Horizonte 1972
Hoffmann, I., Kuch, H., Schmitt, K., Seidl, G.: 2-Äthylamino-6-Chlor-4-Methyl-4-Phenyl-4 H-3,1-Benzoxazin, eine neue, psychotrope Verbindung. Arzneimittel-Forsch. (Drug. Res.) 20, 975 (1970)
Lader, M. H., Wing, L.: Physiological measures, Sedative drugs and morbid anxiety. London: Oxford University Press 1966
Sartory, G., Rust, J.: The effects of a single administration of Etifoxine on several psychological tests. Psychopharmacologia (Berl.) 29, 365–384 (1973)
Taylor, J. A.: A personality scale of manifest anxiety. J. abnorm. Soc. Psychol. 48, 285–290 (1953)
Venables, P. H., Martin, I.: Manual of psychophysiological methods. Amsterdam: North Holland 1967
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Córsico, R., Moizeszowicz, J., Bursuck, L. et al. Evaluation of the psychotropic effect of Etifoxine through pursuit rotor performance and GSR. Psychopharmacologia 45, 301–303 (1976). https://doi.org/10.1007/BF00421144
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DOI: https://doi.org/10.1007/BF00421144