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Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice

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Abstract

Chlordiazepoxide and amphetamine, given separately or in combination, were tested in mice subjected to 5 100-trial avoidance sessions in the shuttle-box.

Facilitation of avoidance responding was much more evident and statistically significant when the two drugs were combined. Drug mixtures produced effects which could not be obtained when the drugs were given separately.

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References

  • Bignami, G., De Acetis, L., Gatti, G. L.: Facilitation and impairment of avoidance responding by phenobarbital sodium, chlordiazepoxide and diazepam. The role of performance base lines. J. Pharmacol. exp. Ther. 176, 725–732 (1971)

    Google Scholar 

  • Boissier, J. R., Simon, P., Lwoff, J. M.: Sur une action paradoxale du chlordiazepoxide. Thérapie 18, 1247–1256 (1963)

    Google Scholar 

  • Bovet, D., Bovet-Nitti, F., Oliverio, A.: Genetic aspects of learning and memory in mice. Science 163, 139–149 (1969)

    Google Scholar 

  • Corrodi, H., Hanson, L. C. F.: Central effects of an inhibitor of tyrosine hydroxylation. Psychopharmacologia (Berl.) 10, 116–125 (1966)

    Google Scholar 

  • Del Rio, J.: Facilitating effects of some chlorpromazine-d-amphetamine mixtures on avoidance learning. Psychopharmacologia (Berl.) 21, 39–48 (1971)

    Google Scholar 

  • Dorr, M., Steinberg, H., Tomkiewicz, M., Joyce, D., Porsolt, R. D., Summerfield, A.: Persistence of dose related behaviour in mice. Nature (Lond.) 231, 121–123 (1971)

    Google Scholar 

  • Edwards, A. L.: Experimental design in psychological research. New York: Holt, Rinehart and Winston 1960

    Google Scholar 

  • Essman, W. B.: Drug effects and learning and memory processes. Advanc. Pharmacol. 9, 241–330 (1971)

    Google Scholar 

  • Fuxe, K., Hanson, L. C. F.: Central catecholamine neurons and conditioned avoidance behaviour. Psychopharmacologia (Berl.) 11, 439–447 (1967)

    Google Scholar 

  • Heise, G. A., Boff, E.: Continuous avoidance as a base-line for measuring behavioral effects of drugs. Psychopharmacologia (Berl.) 3, 264–282 (1962)

    Google Scholar 

  • Lidbrink, P., Corrodi, H., Fuxe, K., Olson, L.: The effects of benzodiazepines, meprobramate, and barbiturates on central monoamine neurons. In: The benzodiazepines, S. Garattini, E. Mussini, and L. O. Randall, eds., pp. 203–223. New York: Raven Press 1973

    Google Scholar 

  • Moore, K. E., Rech, R. H.: Antagonism by monoamine oxidase inhibitors of α-methyltyrosine-induced catecholamine depletion and behavioral depression. J. Pharmacol. exp. Ther. 156, 70–75 (1967)

    Google Scholar 

  • Robichaud, R. C., Sledge, K. L., Hefner, M. A., Goldberg, M. E.: Propranolol and chlordiazepoxide on experimentally induced conflict and shuttle-box performance in rodents. Psychopharmacologia (Berl.) 32, 157–160 (1973)

    Google Scholar 

  • Rushton, R., Steinberg, H.: Drug combinations and their analysis by means of exploratory activity in rats. In: Neuropsychopharmacology, H. Brill, J. O. Cole, P. Deniker, H. Hippius and P. B. Bradley, eds., pp. 464–470. Amsterdam: Excerpta Medica Foundation 1967

    Google Scholar 

  • Rushton, R., Steinberg, H., Tomkiewicz, M.: Effects of chlordiazepoxide alone and in combination with amphetamine on animal and human behavior. In: The benzodiazepines, S. Garattini, E. Mussini and L. O. Randall, eds., pp. 355–366. New York: Raven Press 1973

    Google Scholar 

  • Sachs, E., Weingarten, M., Klein, N. W.: Effects of chlordiazepoxide on the acquisition of avoidance learning and its transfer to the normal state and other drug conditions. Psychopharmacologia (Berl.) 9, 17–30 (1966)

    Google Scholar 

  • Sansone, M., Bovet, D.: Effects of amphetamine on the decrement of performance in avoidance conditioning of guinea pigs. Psychopharmacologia (Berl.) 16, 234–239 (1969)

    Google Scholar 

  • Sansone, M., Renzi, P.: Shuttle-box avoidance behaviour of hamsters: a further investigation on the effects of amphetamine and methylphenidate. Pharmacol. Res. Commun. 3, 113–119 (1971)

    Google Scholar 

  • Sansone, M., Renzi, P., Amposta, B.: Effects of chlorpromazine and chlordiazepoxide on discriminated lever-press avoidance behavior and intertrial responding in mice. Psychopharmacologia (Berl.) 27, 313–318 (1972)

    Google Scholar 

  • Seiden, L. S., Carlsson, A.: Temporary and partial antagonism by l-Dopa of reserpine-induced suppression of a conditioned avoidance response. Psychopharmacologia (Berl.) 4, 418–423 (1963)

    Google Scholar 

  • Seiden, L. S., Peterson, D. D.: Reversal of the reserpine-induced suppression of the conditioned avoidance response by l-Dopa: correlation of behavioral and biochemical differences in two strains of mice. J. Pharmacol. exp. Ther. 169, 422–428 (1968)

    Google Scholar 

  • Sethy, V. H., Naik, P. Y., Sheth, U. H.: Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice. Psychopharmacologia (Berl.) 18, 19–25 (1970)

    Google Scholar 

  • Steiner, S. S., Fitzgerald, H. L., Taber, R. I.: Effect of chlordiazepoxide on acquisition and extinction of shuttle-box and pole-climb avoidance. Pharmacologist 9, 200 (1967)

    Google Scholar 

  • Taylor, K. M., Laverty, R.: The interaction of chlordiazepoxide, diazepam, and nitrazepam with catecholamines and histamine in regions of the rat brain. In: The benzodiazepines, S. Garattini, E. Mussini and L. O. Randall, eds., pp. 191–202. New York: Raven Press 1973

    Google Scholar 

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Sansone, M. Facilitation of avoidance learning by chlordiazepoxide-amphetamine combinations in mice. Psychopharmacologia 41, 117–121 (1975). https://doi.org/10.1007/BF00421067

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  • DOI: https://doi.org/10.1007/BF00421067

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