Abstract
Ratlings born of six drug-addicted and a control group of parent rats were raised under the influence of the same drugs administered in drinking water. They were trained in a conditioned avoidance paradigm (CAR) from the 7th week when the drugs were withdrawn except in two subgroups of flurazepam and morphine. The growth rate was not appreciably impaired except for temporary slowness in morphine and alcohol-raised rats; it was faster in phenobarbitone and meprobamate-raised rats. The CAR-acquisition rates of the treatment groups were quite close and parallel to that of the controls except for the morphine, meprobamate, medazepam and the two drug-trained subgroups; whereas, the rats raised on low-dose morphine showed a faster than control acquisition rate. No evidence of state-dependent learning was obtained from this study.
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References
Banerjee, U.: Acquisition of conditioned avoidance response in rats under the influence of addicting drugs. Psychopharmacologia (Berl.) 22, 133–143 (1971)
Banerjee, U.: Programmed self-administration of potentially addictive drugs in young rats and its effects on learning. Psychopharmacologia (Berl.) 38, 111–124 (1974)
Banerjee, U.: Conditioned avoidance behaviour in pretrained rats intermittently treated with addictive drugs. Physiol. Behav. (in press)
Cook, L., Weidley, E.: Behavioral effects of some psychopharmacological agents. Ann. N.Y. Acad. Sci. 66, 740–752 (1957)
Edwards, R. E.: Methods of detecting behavioral effects of morphine in rats. Fed. Proc. 20, 397 (1961)
Evans, W. O., Smith, R. P.: Some effects of morphine and amphetamine on intellectual functions and mood. Psychopharmacologia (Berl.) 6, 49–56 (1964)
Mello, N. K.: Some aspects of the behavioral pharmacology of alcohol. In: Psychopharmacology—A review of progress, pp. 787–809. Efron, D. H., ed. Washington: U.S. Dept. of Health 1968
Overton, D. A.: State-dependent learning produced by depressant and atropine like drugs. Psychopharmacologia (Berl.) 10, 7–31 (1966)
Sachs, E.: Dissociation of learning in rats and its similarities to dissociated states in man. In: Comparative psychopathology, pp. 249–304. Zubin, J., and Hunt, H., eds. New York: Grune & Stratton 1967
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Banerjee, U. Conditioned learning in young rats born of drug-addicted parents and raised on addictive drugs. Psychopharmacologia 41, 113–116 (1975). https://doi.org/10.1007/BF00421066
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DOI: https://doi.org/10.1007/BF00421066